可降解聚酯多孔支架的常温模压成型  

A "Room-Temperature" Compression Molding Method for Fabrication of Poly (ε-caprolactone) Porous Scaffolds

作　　者：吴林波[1] 张俊川[1] 景殿英[1] 丁建东[1] 

机构地区：[1]聚合物分子工程教育部重点实验室,复旦大学高分子科学系,上海200433

出　　处：《应用化学》2005年第9期1024-1026,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助项目(20221402;20374015);教育部科学技术研究重大项目(305004);高等学校青年教师教学和科研奖励基金;"九七三"项目;"八六三"项目(2004AA215170);上海市科技发展基金(04JC14019)资助

摘　　要：A novel room-temperature compression molding method combined with particulate leaching was(developed) to fabricate porous polyester scaffolds with the anatomical shape of the tissue or organ potentially(applied) in tissue engineering.Complicated-shaped scaffolds,such as auricle-like ones,were successfully fabricated from compression-molding putty-like mixture of concentrated poly(ε-caprolactone) solution and salt particulate in a mould with a complicated-shaped cavity at room temperature.The resultant porosity can reach over 90%.This room-temperature compression molding method is proven to be very convenient to fabricate three-dimensional porous scaffolds composed of biodegradable polymers.A novel room-temperature compression molding method combined with particulate leaching was developed to fabricate porous polyester scaffolds with the anatomical shape of the tissue or organ potentially applied in tissue engineering. Complicated-shaped scaffolds, such as auricle-like ones, were successfully fabricated from compression-molding putty-like mixture of concentrated poly （ ε-caprolactone ） solution and salt particulate in a mould with a complicated-shaped cavity at room temperature. The resultant porosity can reach over 90%. This room-temperature compression molding method is proven to be very convenient to fabricate three-dimensional porous scaffolds composed of biodegradable polymers.

关 键 词：组织工程 多孔支架 可降解聚合物 聚Ε-己内酯 聚合物加工 

分 类 号：O63[理学—高分子化学]