桂麻合方对致热家兔血浆中前列腺素E_2和环磷酸腺苷含量的影响  

Gui-ma Composite Decoction's Effects on the cAMP and PGE_2 in the Serum of Experimental Fever Rabbit

作　　者：李静华[1] 郭玉成[1] 贾春华[1] 李晓军[1] 刘小刚[1] 崔箭[1] 

机构地区：[1]承德医学院,河北承德067000

出　　处：《时珍国医国药》2005年第10期945-946,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金项目(No.30371723);国家中医药管理局项目(No.02-03JP-08)

摘　　要：目的:揭示桂麻合方解热作用协同、拮抗关系的存在及产生的原因。方法:以耳缘静脉注射内毒素复制家兔发热模型,测量口服桂枝汤、麻黄汤及其合方后不同时间的体温采集耳缘静脉血,血液样品按环磷酸腺苷(cAMP)、前列腺素E2(PGE2)药盒要求处理。结果:家兔血中的PGE2和cAMP的变化与体温变化相平行,解热作用有协同或拮抗关系的存在。结论:桂麻合方在煎煮过程中的新整合对PGE2和cAMP含量产生影响,从而使其解热作用出现协同或拮抗关系。Objective：To reveal the existence of antagonistic or synergistic relationship between compositions of Ma huang and Gui-zhi decoction and the reason. Methods： Copy the family rabbit fever model by iv endotoxin （ET） , take the temperature at different time points after administering Gui-zhi decoction, Ma-huang decoction and their compositions, and then collect the vein blood, detect the cAMP and PGE2 in sample according to the specification. Results：The changes of the levels of PGE2 and cAMP are paralleled to the change of temperature. There exists an antagonistic of synergistic relationships in the deferveseenee effect. Conclusion：The new integrations produced in the process of deeocting of Gui-ma composite decoctions have influences on the levels of PGE2 and cAMP, which makes the deferveseenee effect produce the antagonistic or synergistic relationship.

关 键 词：桂麻合方 发热 前列腺素E2 环磷酸腺苷 

分 类 号：R284.2[医药卫生—中药学]