大豆异黄酮对小鼠实验性肝损伤的保护作用  

Protective Effects of Soybean Isoflavones on Experimental Hepatic Injuries

作　　者：曾靖[1] 刘春棋[2] 江丽霞[2] 叶和杨[1] 

机构地区：[1]赣南医学院,江西赣州341000 [2]赣南医学院附属医院,江西赣州341000

出　　处：《时珍国医国药》2005年第10期989-990,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的:探讨大豆异黄酮对小鼠实验性肝损伤的保护作用。方法:采用四氯化碳(CCl4)、硫代乙酰胺(TAA)、扑热息痛(AAP)致小鼠急性肝损伤模型,测定小鼠血清SGPT活性。结果:大豆异黄酮对四氯化碳、扑热息痛致小鼠实验性肝损伤有明显保护作用。大豆异黄酮对硫代乙酰胺所致小鼠实验性肝损伤无明显的保护作用。结论:大豆异黄酮可明显降低四氯化碳、扑热息痛致小鼠急性肝损伤模型血清SGPT活性。而对硫代乙酰胺致小鼠急性肝损伤模型血清SGPT活性无明显作用。Objective：To study the protective effect of soybean isoflaveones on experimental hepatic injuries. Methods： The activity of serum SGPT were measured in the model mice of hepatic injury induced by carbon tetrachloride （CCl4）, Acetaminophen （AAP） and Thioaeetamide （TAA）. Results： The serum SGPT activity was significantly lowered in the model mice of hepatic injuries induced by CCl4, AAP and TAA after soybean isoflavones was given orally. Conclusion： Soybean isoflavones exhibited protective effect on experimental hepatic injuries.

关 键 词：大豆异黄酮 肝损伤 谷丙转氨酶 

分 类 号：R285.5[医药卫生—中药学]