黄杨宁滴丸对实验性急性心肌缺血的改善作用  

Protection Effects of Huangyangningdiwan on Experimental Acute Myocardial Inf arction Rats

作　　者：吴著群 俞浩[2] 刘海鹏[3] 

机构地区：[1]上海海虹实业<集团>巢湖中辰药业有限公司,安徽巢湖238000 [2]安徽技术师范学院中药学教研室,安徽凤阳233100 [3]安徽中医学院药理教研室,安徽合肥230038

出　　处：《中国药业》2005年第9期28-30,共3页China Pharmaceuticals

摘　　要：目的:观察黄杨宁滴丸对实验性急性心肌缺血的改善作用。方法:结扎大鼠冠状动脉左前降支建立急性心肌缺血模型,观察大鼠心电图、肌酸激酶(CK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)、丙二醛(MDA)、血栓素B2(TXB2)、6-酮前列腺素F1α(6-Keto-PGF1α)、心肌梗塞区重量及心肌病理组织学变化。结果:黄杨宁滴丸能明显改善心肌缺血大鼠心电图,降低血清CK,LDH,MDA,TXB2水平,升高血浆SOD,6-Keto-PGF1α水平,减轻心肌梗塞区重量及心肌病变程度。结论:黄杨宁滴丸对大鼠急性心肌缺血具有改善作用。Objective： To observe the protection effects of Huangyangningdiwan（HYNDW）on acute myocardial infarction experimental rats. Methods： The myocardial infarction model of rats was induced by ligating the anterior branch of left coronary artery. The change of cardiogram, CK, LDH, SOD, MDA, TXB2,6-Keto-PGF1α, myocardial infarction weight and pathological tissue were observed. Results： HYNDW can obviously improve cardiogram, reduce the level of CK, LDH, MDA and TXB2, highten the level of SOD and 6-Keto-PGF1α,lighten myocardial infarction weight and cardiac muscle pathological change degree. Conclusion： HYNDW can protect the acute myocardial infarction of rats.

关 键 词：黄杨宁滴丸 冠状动脉 心肌缺血 实验研究 

分 类 号：R965[医药卫生—药理学] R972[医药卫生—药学]