高原应激对大鼠脑内β－内啡肽含量的影响  

THE EFFECT OF HIGH ALTITUDE STRESS ON β-ENDORPHIN CONTENTS OF RATS BRAIN

作　　者：谢新民[1] 孟宪纪[1] 高玉琴[1] 

机构地区：[1]青海医学院,青海省人民医院内科

出　　处：《高原医学杂志》1996年第1期34-37,共4页Journal of High Altitude Medicine

基　　金：青海省卫生厅

摘　　要：本工作选用成年雄性Ｗｉｓｔａｒ大鼠，由平原（海拔５ｍ）直接运送到海拔２２６ｌｍ和３４６０ｍ高原现场。在２４小时急性习服期，以放射免疫测定法（ＲＩＡ），研究了大鼠脑垂体及各项区内β－内啡肽样免疫活性物质（ｉｒ－β－ＥＰＬＩ，β－ＥＰ）的含量变化结果表明，大鼠在高原２２６１ｍ和３４６０ｍ急性习服期，与平原者对照组相比，垂体内β－ＥＰ含量降低非常显著（Ｐ＜０．０１），纹状体、下丘脑、丘脑、桥延、皮层、海马内β－ＥＰ含量增加非常显著（均为Ｐ＜０．０１）。据此认为，哺乳动物急进高原低氧环境后在应激状态下，中枢内β－ＥＰ的合成与分泌受到明显影响。提示，脑内β－ＥＰ参与高原应激反应过程。he effect on β-endorphin(β-EP)contents in the brain of rats which were taken to theplateau(2 26lm,Xining,3 460m,Tianju ,Qinghai)was studied by means of radioimmunoassaythe results showed that the contents of β-EP in hypophysis were decreased(P<0.01)and thecontents of β-EP in copus striatum,hypothalamus,thalamus,ponsoblongata,hippocampus,mes-encephalon were increase(P<0.0l),but the content of β-EP in cortex was not significantly in-creasd(P<0.05)when compared with control group. From this result we consder that β-EPof the brain in rats may take part in the stress reaction to acute hypoxia.

关 键 词：高原应激 Β-内啡肽 高原病 

分 类 号：R594.302[医药卫生—内科学]