RTX膀胱灌注治疗间质性膀胱炎的临床观察  

Randomized Controlled Clinical Trial of Irrigation of the Bladder with Resiniferatoxin (RTX) for the Treatment of Interstitial Cystitis

作　　者：王风[1] 梅红兵[1] 曹清丽[1] 叶少波[1] 

机构地区：[1]深圳市第二人民医院泌尿外科,深圳市518035

出　　处：《中国医院用药评价与分析》2005年第4期240-242,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨膀胱灌注resiniferatoxin(RTX)治疗间质性膀胱炎(IC)的临床效果。方法:16例IC随机分成试验组(A组)和对照组(B组)。A组9例,B组7例。A组用0.5%利多卡因溶液40ml从导尿管注入膀胱,保留5分钟后全部排出;用0.0063mg%RTX100ml灌注膀胱,保留30min后排空。B组用1∶5000呋喃西林(安慰剂)替代RTX,方法类同A组。观察两组用药前、用药后1月、用药后3月的临床症状(每日排尿次数、夜尿次数、尿急和尿痛程度)和尿动力学参数(FDV、MCC、Qmax)。结果:两组用药前与用药后1月、用药后3月比较无显著性差异(P>0.05)。RTX不能改善IC的临床症状和尿力学参数。结论:用0.0063mg%RTX单剂量膀胱灌注治疗IC无效。OBJECTIVE：To evaluated clinical effect of irrigation of the bladder with Resiniferatoxin（RTX） for the treatment of interstitial cystitis（IC） . METHODS： 16 cases with IC were randomly divided into test group A（9 cases） and control group B （7 cases）. The patients in group A were treated by irrigation of the bladder with 0.5% lidocain 40ml remained within the bladder for 5 minutes at first, then with 0.0063mg% RTX 100ml remained within the bladder for 30 minutes, finally the drugs were evacuated. The patients in group B were treated by the same method but with furacilin solution（placebo） at a dilution 1：5 000 instead of 0.0 063mg% RTX. Clinical efficacy （daily emiction frequency, nocturia frequency, urgency and odynuria degree） and urine kinetic parameters （FDV, MCC, Qmax） of the 2 groups before treatment, 1 month and 3 months after treatment were evaluated. RESULTS： There was no significant difference between two groups before treatment, 1 month and 3 months after treatment（ P 〉 0.05）. RTX could not improve clinical symptoms and urine kinetic parameters of interstitial cystitis. CONCLUSION： Single use of 0.0 063mg% RTX 100ml is not effective for the patients with IC.

关 键 词：RESINIFERATOXIN 间质性膀胱炎 随机对照 

分 类 号：R978[医药卫生—药品]