红花总黄素对离体大鼠心脏保护作用的实验研究  

EXPERIMENTAL STUDY ON PROTECTIVE EFFECT OF SAFFLOR YELLOW ON RATS′ISOLATED HEARTS

作　　者：郑为超[1] 张超[1] 

机构地区：[1]安徽理工大学医学院,淮南232001

出　　处：《中国中医药科技》2005年第5期295-296,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：安徽省重点科研项目资金资助课题No.01041183

摘　　要：目的探讨红花总黄素(SY)对离体大鼠心脏的保护作用。方法以离体大鼠心脏为观测对象,观察其在4℃10%SY和单纯生理盐水中保存不同时间时,观察各不同时间心肌组织中一氧化氮(NO)、丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性的变化情况。结果组内各时点间比较SY组5h心肌中NO含量与0h相比有显著性差异(P<0.05),余均无显著性改变;对照组在各时点NO和MDA含量、SOD活性均与0h有显著性差异(P<0.05)。组间各指标比较自2h起,各时点SY组NO含量和SOD活性均显著高于对照组,MDA含量均显著低于对照组(P<0.05)。结论红花总黄素能较明显的减轻自由基对缺血心肌的损伤,延长心肌存活时间。可考虑通过进一步研究将其应用于心脏移植供心的保护。Objective:To study the protection effects of safflor yellow on rat′s isolated-heart.Methods:50 rats were randomly divided into two groups,in one group,the rats′ isolated-hearts were perfused and preserved with 4℃ 10% safflor yellow in saline,the others with only saline,the isolated hearts were preserved and then detected the contents of nitric oxide(NO),malondialdehyde(MDA)and superoxide dismutase(SOD)in myocardium.Results:Safflor yellow could increase the content of NO and activities of SOD,decrease the content of MDA in myocardium.Conclusion:Safflor yellow may obviously prevent the damage of the rats′ isolated-hearts which may be related to its anti-free radical.

关 键 词：红花总黄素 离体心脏 大鼠 保护作用 实验研究 中医药疗法 

分 类 号：R285[医药卫生—中药学]