滴鼻灵的研制和临床应用  

Trituration and clinical application of dibiling nasal drops

作　　者：马敏[1] 马华[1] 张京平[1] 赵海亮[1] 安云芳[1] 

机构地区：[1]山西医科大学第二医院,030001

出　　处：《山西医药杂志》2005年第9期715-717,共3页Shanxi Medical Journal

基　　金：山西省教委科技资助项目(2024)

摘　　要：目的开发治疗急性鼻炎、鼻窦炎纯中药滴鼻剂。方法①选苍耳子散加减,采用水提醇沉法制备成滴鼻剂。②急性鼻炎90例,急性鼻窦炎73例,各随机分为两组,治疗组用滴鼻灵治疗,对照组用呋麻液治疗。结果①滴鼻灵留样观察1年。澄明度无改变,pH值稳定,无沉淀和絮状物。②治疗组有效率,急性鼻炎、鼻窦炎分别为90.9%,89.5%;对照组分别为73.9%,68.6%(P<0.05)。结论滴鼻灵治疗急性鼻炎、鼻窦炎疗效确切,无明显不良反应。Objective To exploit pure Chinese herbal medicine nose drops for treating acute rhinitis and sinusitis. Methods ①Using xanthium powder with a modified recipe to make nasal drops by means of ＂water-extraction following alcohol-precipitation＂. ②Ninety patients of acute rhinitis and 73 patients of acute sinusitis were randomly divided into two groups respectively. Treatment teams were treated with dibiling, control teams were treated with furacilinephedrine mixture. Results ①The reserved sample of dibiling was examined after one year, its clarity did not change, pH value remained stationary;no deposit and floccule occurred. ②The effective rate of treatment team （90.9% and 89. 5% ） was significantly higher than that of control team （73.8% and 68.6% ） for acute rhinitis and sinusitis respectively （P〈0.05）. Conclusion Dibiling is effective for treating acute rhinitis and sinusitis,without evident adverse reaction.

关 键 词：鼻炎 鼻窦炎 临床试验 滴鼻灵 临床应用 急性鼻窦炎 中药滴鼻剂 急性鼻炎 研制 治疗组 

分 类 号：R287[医药卫生—中药学]