在线电生次氯酸根流动注射化学发光法测定卡托普利  

Flow Injection Chemiluminescence Determination of Captopril with On-line Electrogenerated Hypochlorite

作　　者：李献锐 王庆飞[1] 申金山[1] 童汝亭[1] 

机构地区：[1]河北师范大学化学学院

出　　处：《河北师范大学学报（自然科学版）》2005年第5期491-493,498,共4页Journal of Hebei Normal University：Natural Science

基　　金：河北省科学技术厅攻关项目(04276405)

摘　　要：将在线恒电流电解产生ClO-与流动注射化学发光法结合,基于卡托普利能抑制ClO-luminol化学发光,其质量浓度与抑制作用的大小呈线性关系,建立了测定卡托普利流动注射化学发光新方法.卡托普利在0～17mg/L范围内与空白、试样信号差值呈线性关系,相关系数为0.999 6,相对标准偏差为2.8%,该法具有简单、快捷、灵敏等特点.用于药剂中卡托普利含量的测定,结果与药典方法测得值一致.A novel flow injection chemiluminescence method with electogenerated hypochlorite for the determination of captopril based on its inhibition of chemiluminescence from luminol-hypochlorite system is described. The linear range for captopril is 0～17mg/L. The relative standard deviation is 2.8%（n=11, ρ=10 mg/L）. The proposed method is simple, rapid and sensitive, and has been applied to the determination of captopril in the tablets with satisfactory results.

关 键 词：电解 流动注射 化学发光 次氯酸根 卡托普利 

分 类 号：O656[理学—分析化学]