离心造粒法制备盐酸二甲双胍缓释微丸  

Preparation of Sustained-release Pellets of Metformin Hydrochloride Using Centrifugal Granulation Method

作　　者：胡连栋[1] 唐星[1] 丁怡[1] 张倩[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国医药工业杂志》2005年第9期541-544,共4页Chinese Journal of Pharmaceuticals

摘　　要：在盐酸二甲双胍微丸外依次包滑石粉隔离层和Eudragit缓释层,并考察两者对体外释放度的影响。采用EudragitNE30D-L30D55(20∶1)包衣所得微丸表现出缓释特征,在体内与参比制剂生物等效。The metformin hydrochloride pellets were coated in turn with talc powder and Eudragit as the isolating layer and Sustained-release layer. The effects of the two layers on the in vitro release of the pellets were investigated. The results showed that the pellets covered with Eudragit NE30D-L30D 55 （20 ： 1） had a sustained-release property and was bioequivalent to reference preparation.

关 键 词：盐酸二甲双胍 缓释 微丸 包衣 离心造粒 生物等效 

分 类 号：R944.9[医药卫生—药剂学] R977.15[医药卫生—药学]