填充剂对环孢素A固体分散体颗粒粉体学性质的影响  

Effects of Fillers on Micromeritic Properties of Cyclosporin A Solid Dispersion Particles

作　　者：柳晨[1] 吴君华[1] 裴元英[1] 

机构地区：[1]复旦大学医学院药剂学教研室,上海200032

出　　处：《中国医药工业杂志》2005年第9期555-556,共2页Chinese Journal of Pharmaceuticals

摘　　要：Cyclosporin A solid dispersion particles containing lactose, pregelatinized starch and microcrystalline cellulose respectively were prepared by wet granulation method. The hygroscopic behavior, bulk density and angle of repose of these particles were investigated. The results showed that the three fillers could increase the bulk density and flowability. The critical relative humidity for the particles with or without lactose was about 82%.Cyclosporin A solid dispersion particles containing lactose, pregelatinized starch and microcrystalline cellulose respectively were prepared by wet granulation method. The hygroscopic behavior, bulk density and angle of repose of these particles were investigated. The results showed that the three fillers could increase the bulk density and flowability. The critical relative humidity for the particles with or without lactose was about 82%.

关 键 词：环孢素A 亲脂性环状多肽 载体材料 填充剂 分散体颗粒 粉体学性质 流动性 

分 类 号：TQ465.6[化学工程—制药化工]