海洛因依赖患者局部脑血流灌注改变研究  

A study on regional cerebral blood flow in heroin-addicted patients

作　　者：陈跃[1] 黄占文[1] 陈礼刚 刘科[1] 谭蓓蓓[1] 

机构地区：[1]泸州医学院附属医院,四川泸州646000

出　　处：《中国临床医学影像杂志》2005年第9期492-493,共2页Journal of China Clinic Medical Imaging

摘　　要：目的:探讨海洛因依赖者局部脑血流(rCBF)表现,并提高对本病的认识。方法:141例海洛因依赖者静脉注射99mTc-ECD740MBq,30min后行局部脑血流灌注SPECT显像。结果:141例海洛因依赖者136例(96.5%)见rCBF减低。46例(33%)显示1处rCBF减低,68例(48%)为同时存在2处rCBF减低,17例(12%)为同时存在3处rCBF减低,3例(2.1%)为同时存在4处rCBF减低,2例(1.4%)为同时存在5处rCBF减低。海洛因依赖者rCBF减低主要见于顶叶、额叶、枕叶和颞叶。结论:海洛因依赖者可能存在顶叶、额叶和颞叶功能低下,rCBF检测对海洛因依赖有诊断价值。Objective： To investigate the changes of regional cerebral blood flow（rCBF） of heroin addicts and to improve the knowledge of this disease. Methods： One hundred and forty-one heroin-dependent individuals were scanned with single photon emission computed tomography（SPECT） and their rCBF were obtained 30min later after injection of ^88mTc-ethylene cysteinate dimer（ECD） 740MBq. Results： A decrease in rCBF was found in 136 patients（96.5%）. Forty-six（33%） patients had one low rCBF focus. Sixty-eight（48%） patients had two low rCBF foci. Seventeen（12%） patients had three low rCBF foci. Three（2.1%） patients had four low rCBF foci. Two（l.4%） patients had five low rCBF foci. The decrease of rCBF was distributed mainly in parietal lobe, temporal lobe, frontal lobe. Conclusions： Low rCBF of parietal lobe, temporal lobe, frontal lobe may be detected in heroin-addicted patients. These results suggest that rCBF is of value in the diagnosis of heroin addicts with low rCBF of parietal lohe, temporal lobe, frontal lobe and thalamencephalon.

关 键 词：海洛因依赖 血液灌注 脑疾病 体层摄影术 发射型计算机 单光子 

分 类 号：R996[医药卫生—毒理学] R742[医药卫生—药学]