丙种球蛋白联合糖皮质激素治疗自身免疫性大疱病26例观察疗效  

Therapeutic Observation of Intravenous Gammaglobulin in Combination with Corticosteriods on 26 Cases of Autoimmune Bullous Diseases

作　　者：眭洪峰 孙新芬[2] 翁孟武[2] 

机构地区：[1]江苏省丹阳市人民医院,江苏丹阳212300 [2]复旦大学附属华山医院,上海200040

出　　处：《中国皮肤性病学杂志》2005年第9期539-540,共2页The Chinese Journal of Dermatovenereology

摘　　要：目的评价大剂量丙种球蛋白在治疗自身免疫性大疱病方面的疗效。方法对应用较大剂量糖皮质激素1周以上疗效不佳的自身免疫性大疱病患者加用大剂量丙种球蛋白静脉注射治疗。结果所有患者应用丙种球蛋白后均取得明显效果,92.3%的患者2～5天后水疱停止发生,尼氏征转阴,黏膜损害消退。结论大剂量静脉注射丙种球蛋白对大剂量糖皮质激素疗效不佳的重症患者是一种很好的辅助治疗方法。Objective To assess the effect of high dose of intravenous gammaglobulin on the autoimmune bullous diseases.Methods Additional high dose of intravenous gammaglobulin was used in the patients who had no response to the high dose of eorticosteriods after more than one week treatment.Results It produced beneficial effect on all the patients.There was no new bulla after 2-5days in 92.3% of the patients and the Niksky sign turned negative and the mucosal lesions disappeared.Conclusion High dose of intravenotts gammaglobulin is a good adjunct treatment for the severe patients who fail to respond to the large dose of glucocorticostcriod.

关 键 词：丙种球蛋白 糖皮质激素 自身免疫性大疱病 

分 类 号：R758.66[医药卫生—皮肤病学与性病学] R457.2[医药卫生—临床医学]