O139群霍乱弧菌L型变异和诱导实验的观察及致病性的探讨  

Laboratory Research on L-form Variation and Pathogenicity of Vibrio Cholerae O139

作　　者：段玉芹[1] 王显军[1] 崔树玉[1] 杨彬[1] 陈志林[1] 冯开军[1] 毕振强[1] 

机构地区：[1]山东省疾病预防控制中心,山东济南250014

出　　处：《预防医学论坛》2005年第5期525-527,共3页Preventive Medicine Tribune

摘　　要：[目的]探讨O139群霍乱弧菌L型变异及其与ElTor型的R型血清的关系。[方法]2002～2005年,我们采用酚肉汤传代、抗生素、胆盐和蒸馏水等实验室诱导方法进行观察。[结果]发现O139群霍乱弧菌6菌株经上述方法诱导可发生L型变异,其菌落特征和菌体形态均与L型的描述相符。[结论]实验结果证实O139群霍乱弧菌可诱导成L型,通过与O1群的R型血清凝集状况,表明其L型菌株未见到抗原的完全消失,其变异过程与ElTor弧菌相似,关系密切,推测自然界中亦存在O139群霍乱弧菌L型,且仍具有致病性。[Objectlve]To discuss the Variation of Vibrio cholerae O139 L-forms anf the correlation between the I. form and R-form sernm. [Methods]To observe the variation of Vibrio cholerae O139 L-forms with induction of antibiocs,sodium deoxycholate and distiIled water. [Results] L-forms of Vibrio cholerae O139 , whose characteristics of colonies and morphology of bacteria were accorded to L-forms, may be induced by antibiocs, sodium deoxycholate and distilled water. [Conclusion]Vibrio cholerae O139 L-forms can be induced. The variabIe procedure is similar to Vibrio cholerae El Tor. It is possibIe that there exist L-forms of Vibrio cholerae O139 in natural environment.

关 键 词：O139群霍乱弧菌 诱导 L型 变异 

分 类 号：R516.5[医药卫生—内科学]