侧脑室注射内吗啡肽-1对大鼠心功能的影响  

Influence of intracerebroventricular administraction of endomorphine-1 on left venteicular systolic pressuer in rats

作　　者：胡杰[1] 汪思应[1] 李正红[2] 

机构地区：[1]安徽医科大学,安徽合肥230032 [2]蚌埠医学院生理学教研室,安徽蚌埠233003

出　　处：《蚌埠医学院学报》2005年第5期390-392,共3页Journal of Bengbu Medical College

基　　金：安徽省教育厅自然科学研究资助项目(2002kj205)

摘　　要：目的:观察侧脑室注射内吗啡肽-1(EM-1)对麻醉大鼠心功能的影响,探讨其作用机制。方法:麻醉大鼠侧脑室埋植导管给药,右颈总动脉插管测心功能。结果:侧脑室注射EM-1,Cyprodime敏感减弱大鼠左心室功能。结论:侧脑室注射EM-1能引起麻醉大鼠在体心功能下降而降低动脉血压,此效应由阿片受体介导,通过兴奋迷走神经所致。Objective：To observe the influence of intracerebroventricular administraction of endomorphine-1 on the left venteicular systolic pressuer（LVSP） in anesthetized rats and to assess its mechanism. Methods：Variations of LVSP were observed after injecting andomorphin-1 in anesthetized rats. Results：Endomorphin-1 decreased the LVSP. The decrease in LVSP was blocked by cyprodime. Cortelusions： Intracerebroventricular administration of endomorphin-1 produces depression on the LVSP in the anesthetized rats, which is mediated by opioid receptor,associated with the central mcholinoceptor and the excitation of the vagus.

关 键 词：吗啡衍生物 内吗啡肽 受体 内啡肽 左心室收缩压 大鼠 

分 类 号：R971[医药卫生—药品]