壳糖止血海绵的质量研究  

Study on the quality control of chitosan hemostatic sponge

作　　者：宋炳生[1] 李汉宝[1] 

机构地区：[1]南京军区南京总医院药学部,江苏南京210002

出　　处：《医学研究生学报》2005年第9期790-792,i0011,共4页Journal of Medical Postgraduates

基　　金：南京市2002年第八批科技发展计划资助项目(批准号:20028006)

摘　　要：目的:为壳糖止血海绵制订质量标准。方法:研究壳聚糖、盐酸利多卡因、诺氟沙星的定性方法,检查了海绵的吸水率,采用酸碱萃取分离及紫外分光光度法测定盐酸利多卡因、诺氟沙星含量。结果:定性鉴别试验满意,海绵体吸水率20倍以上,盐酸利多卡因的平均含量为9.55 mg/g,诺氟沙星为8.46 mg/g,加样回收试验盐酸利多卡因、诺氟沙星回收率分别为97.9%和96.5%。结论:该方法可供壳糖止血海绵制订质量标准用。Objective ： To establish a method for quality control of chitosan hemostatic Sponge. Methods： To study the indentification of chitosan , Lidocaine Hydrochloride ,Norfloxacin and inspect the suction water of sponge. Extracting Lidocaine Hydrochloride and Norfloxacin with acid and alkali then determining the content of them by spectrophotometic method. Results： The indetifieation experiment showed a good result . The suction water of sponge outstripped more than 20 times. The average content of Lidocaine Hydrochloride was 9.55 mg/g , Norfloxacin was 8.46 mg/g. The average recovery of Lidocaine Hydrochloride and Norfloxacin was 97.9% and 96.5%. Conclusion ： This method can be used to establish the quality control of chitosan hemostatic sponge.

关 键 词：壳聚糖 止血海绵 质量控制 

分 类 号：R973.1[医药卫生—药品]