爱泼斯坦-巴尔病毒潜伏膜蛋白1的结构和信号转导  

The structure of epstein-barr virus latent membrane protein 1 and its signal transduction

作　　者：何迎春[1] 田道法[1] 

机构地区：[1]湖南中医学院基础部,湖南长沙410007

出　　处：《医学研究生学报》2005年第9期837-840,844,共5页Journal of Medical Postgraduates

基　　金：中国博士后科学基金资助项目(批准号:2004035644);湖南省杰出青年基金资助项目(批准号:03JJY3040);湖南省教育厅科研基金资助项目(批准号:03C287)

摘　　要：爱泼斯坦-巴尔病毒(EBV)是具有致瘤潜能的疱疹病毒,与多种恶性肿瘤的发生相关。近年来,对EBV潜伏感染膜蛋白1(LMP1)的结构、功能及其介导的信号转导通路的研究取得了显著进展。作者就LMP1通过核因子-κB(NF-κB)、活化蛋白1(AP-1)、双面联胎激酶(JAK)/信号转导和转录激活子(STAT)、Ets1、丝裂原激活的蛋白激酶(MAPK)/激活转录因子2(ATF2)途径和细胞周期依赖性激酶(Cdk)途径等,对细胞的生长、增殖、转化、分化、运动和凋亡的调控作一综述。Epstein-Barr virus is a kind of herpes virus that has oncogenic potential and is related to the tumorgenesis process of various malignancy. Important advances have been obtained on the study of the structure and functions of Epstein-Barr virus（EBV） latent membrane protein 1 （LMP1） and signal transduction pathways mediated by LMP1 in recent years. LMP1 could regulate cellular growth, proliferation, transformation, differentiation, transference and apoptosis by means of signal transduction pathways such as NF-kB, AP-1, JAK/STAT, Ets1, MAPK/ATF2 and cyclin dependent kinase.

关 键 词：爱泼斯坦-巴尔病毒 潜伏膜蛋白1 结构 功能 信号转导 

分 类 号：R373.9[医药卫生—病原生物学]