Synthesis of Nonionic Oligomeric Manganese(Ⅱ) Complexes and Investigation of Their Toxicity andΤ_1-Relaxation Enhancement  

作　　者：YU Kai-chao LI Ying-xia ZHOU Jin-lan DING Shang-wu YE Chao-hui 

机构地区：[1]State Key Laboratory of Magnetic Resonance ＆ Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430071, P. R. China [2]Department of Chemistry, Huazhong University of Sciertce and Technology, Wuhan 430074, P. R. China

出　　处：《Chemical Research in Chinese Universities》2005年第5期512-516,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(Nos. 20275011 and 10234070); the Program for PromotingUniversity Academic Excellence by the Ministry of Education of Taiwan of China(No. A-92-N-FA01-2-4-5) ;Foundation of StateKey Laboratory of Magnetic Resonance &Atomic and Molecular Physics(No. T12045).

摘　　要：Six nonionic oligomeric manganese （ Ⅱ ） complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal relaxivities of these complexes were measured. One of these complexes, which showed the highest relaxivity, was chosen to be used in the acute toxicity test and the T1-weighted imaging experiment. It has been found that compared to Gd-DTPA, this nonionic oligomeric Mn（ Ⅱ ） complex exhibits no acute toxicity, generates highly enhanced MRI signals and increases the intention time in the rat liver tissue.Six nonionic oligomeric manganese （ Ⅱ ） complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal relaxivities of these complexes were measured. One of these complexes, which showed the highest relaxivity, was chosen to be used in the acute toxicity test and the T1-weighted imaging experiment. It has been found that compared to Gd-DTPA, this nonionic oligomeric Mn（ Ⅱ ） complex exhibits no acute toxicity, generates highly enhanced MRI signals and increases the intention time in the rat liver tissue.

关 键 词：Magnetic resonance imaging（ MRI） Oligomeric contrast agent Nonionic Mn（ Ⅱ ） complex Relaxivity Acute toxicity Relaxation enhancement 

分 类 号：O614.711[理学—无机化学]