长期饮酒对浙江景宁畲族人群血压、血脂及肾功能的影响  

Effects of Alcohol Intake on Blood Pressure, Serum Lipids and Renal Function in JingNing SHE Chinese

作　　者：李燕[1] 高平进[1] 王谷亮[1] 钱岳晟[1] 王继光[1] 朱鼎良[1] 

机构地区：[1]上海第二医科大学附属瑞金医院上海市高血压研究所,上海200025

出　　处：《高血压杂志》2005年第9期573-577,共5页Chinese Journal of Hypertension

基　　金：国家科技部863计划资助项目(2002BA711A05)

摘　　要：目的探讨长期过量饮酒对血压、血脂及肾功能的影响.方法在浙江省景宁畲族自治县随机选择6个自然村,运用水银柱血压计听诊法连续测量坐位右臂血压3次,取平均值用做统计分析.运用问卷收集饮酒、吸烟、高血压用药史.采集静脉血,全自动生化仪检测血脂及肾功能.结果 1 168例畲族受检者中包括648名(0.55)女性,372例(0.32)高血压患者,526例(0.45)有饮酒习惯,325例(0.28)每周饮酒超过300 g.和不饮酒者相比,饮酒者的收缩压(130.6比126.0 mm Hg)、舒张压(81.0比78.7 mm Hg)、脉压(49.6比47.2 mm Hg)、高密度脂蛋白胆固醇(1.48比1.33 mmol/L)、血尿酸(342比331 μmol/L)明显升高(P<0.01).在畲族男性中,收缩压及舒张压随饮酒量的增加呈线性增加(P<0.01);饮酒是高血压的一个独立的危险因素 (OR, 1.61; 95%可信区间, 1.05～2.47; P=0.03).结论长期过量饮酒可升高血压,增加高密度脂蛋白胆固醇及血尿酸水平.Objective To investigate the effects of sustained drinking on blood pressure, serum lipids and renal function. Methods We randomly selected residents in 6 villages from the JingNing County, ZheJiang Province. Each participant＇s blood pressure was measured and 3 consecutive readings were averaged for analysis. Questionnaire was used to collect information on alcohol consumption, smoking habits, and use of antihypertensive drugs. Venous blood was sampled and serum lipids, creatinine and uric acid were determined. Results 1168 SHE Tribe participants were studied including 648 （0.55） women and 372 （0.32） hypertensive patients. 526（0.45） subjects had drinking habit and 325 （0.28） consumed more than 300 grams of alcohol per week. Compared to non-drinkers, drinkers had significantly （P〈0.01） higher systolic （130.6 vs 126.0 mm Hg） and diastolic blood pressure （81.0 vs 78.7 mm Hg）, pulse pressure （49.6 vs 47.2 mm Hg）, high density lipoprotein cholesterol （1.48 vs 1.33 mmol/L） and serum uric acid （342 vs 331 mol/L）. Only in men but not in women, blood pressure was linearly increased with the amount of alcohol consumption. Logistic analyses showed that alcohol intake was an independent risk factor for hypertension in men （OR, 1.61; 95% CI, 1.05 to 2.47, P=0.03）. Conclusions Alcohol consumption increases blood pressure, high density lipoprotein cholesterol and serum uric acid.

关 键 词：饮酒 血压 血脂 肾功能 人群研究 景宁畲族 长期饮酒 人群血压 浙江省 高密度脂蛋白胆固醇 

分 类 号：R54[医药卫生—心血管疾病]