石英粉尘接尘人员红细胞膜丙二醛负荷分类Logistic回归分析  

Non-conditional Logistic regression analysis on erythrocyte membrane MDA burden in workers exposed to quartz dust

作　　者：胡大林[1] 刘移民[2] 唐冬生[1] 杨建平[2] 彭晓春[3] 胡恭华[2] 方道奎[2] 沙焱[2] 涂晓志[2] 庄志雄[2] 

机构地区：[1]佛山科学技术学院医学院,广东佛山528000 [2]中山大学公共卫生学院预防医学系 [3]国家环保总局华南环境科学研究所,510655

出　　处：《中国职业医学》2005年第5期6-8,共3页China Occupational Medicine

基　　金：广东省医学科学技术研究基金项目(B2002117);佛山市重点科技攻关项目(02080051)

摘　　要：目的探讨石英粉尘接尘人员外周静脉血红细胞膜丙二醛(MDA)负荷分类情况的主要影响因素。方法运用整群抽样研究方法,抽取陶瓷企业石英粉尘健康接尘人员179名,采集外周静脉血2 m l,肝素钠抗凝,以硫代巴比妥法检测红细胞膜MDA负荷,计算MDA的平均负荷作为标准参考值;利用调查表对接尘人员的10个可能影响因素进行调查;同时,对厂内各工序点的生产环境噪声及粉尘浓度进行监测;以接尘人员MDA负荷分类(设大于或小于标准参考值的二分变量)为应变量,以被调查的10个可能影响因素为自变量,运用成组资料的非条件Logistic回归分析模型拟合回归曲线,探寻主要影响因素。结果工龄、粉尘浓度、是否经常佩戴防护口罩、饮茶情况及吸烟等5个因素,最终进入回归方程(α=0.05)。结论进入回归方程的5个因素为影响接尘工人红细胞膜MDA负荷的最主要因素。Objective To explore the main influence factors of MDA burden in erythrocyte membrane in workers exposed to quartz dust. Methods Cluster sampling method was used to investigate 179 workers exposed to quartz dust in ceramics factories in Foshan city, Guangdong province. 2ml venous blood was drawn from the above individuals. The quantity of MDA in erythrocyte membrane was tested by the method introduced in reagent kits, and the mean of MDA was calculated. At the same time, 10 kinds of possible influence factors were investigated by seff-made questionnaire , the concentration of quartz dust in the air and the noise in different work places in the factories were measured. The mean of MDA acted as reference standard, quantity of MDA acted as independent variable, the up-related 10 factors acted as dependant variable, Logistic regression analysis was used to explore the main influence factors. Results The 5 factors including length of work, concentration of quartz dust, whether or not wearing masks, tea-drinking and cigarette smoking were eventually conducted into the regression equation（ α= 0. 05 ）. Conclusion The 5 conducted factors were the main influence factors of quantity of MDA in erythrocyte membrane in human exposed to quartz dust.

关 键 词：石英粉尘 MDA 红细胞膜 LOGISTIC回归 

分 类 号：R135.2[医药卫生—劳动卫生]