氧化苦参碱治疗慢性乙型肝炎疗效观察  

Therapeutic effect of oxymatrine on patients with chronic hepatitis B

作　　者：刘征波[1] 谢玉桃[1] 沙新平[1] 谭德明[1] 

机构地区：[1]中南大学湘雅医院传染科,湖南长沙410008

出　　处：《中国现代医学杂志》2005年第17期2678-2679,2682,共3页China Journal of Modern Medicine

摘　　要：目的观察氧化苦参碱对慢性乙型肝炎的治疗效果。方法80例慢性乙型肝炎患者随机分成两组,治疗组50例,予氧化苦参碱加常规护肝治疗,对照组30例,仅予常规护肝治疗。结果治疗24周后,治疗组较对照组血清总胆红素、丙氨酸转氨酶、门冬氨酸转氨酶下降明显(P<0.01)。治疗组HBeAg与HBVDNA阴转率明显高于对照组(P<0.01)。结论氧化苦参碱对慢性乙型肝炎的具有良好疗效。[Objective] To observe the therapeutic effect of oxymatrine on chronic hepatitis B. [Methods] 80 patients with chronic hepatitis B were divided randomizedly into two groups, 50 patients in oxymatrine group received oxymatrine and regular therapy, while 30 patients in control group only received regular therapy. [Results] After 24 weeks of treatment, the serum total bilirubin （TBIL）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST） were significantly lower in oxymatrine group than in control group, while the negative seroconversion rate of HbeAg and HBV DNA were significantly higher in oxymatrine group than in control group. [Conclusion] Oxymatrine had good therapeutic effect on patients with chronic hepatitis B.

关 键 词：氧化苦参碱 乙型肝炎 疗效 

分 类 号：R512.62[医药卫生—内科学]