可吸收球囊制作的实验研究  

Experimental Study on the Production of Absorbable Balloon

作　　者：周云[1] 唐天驷[1] 熊成东 陈海啸[3] 杨惠林[1] 程华强[4] 潘高峰 

机构地区：[1]苏州大学附属第一医院骨科,江苏苏州215006 [2]四川迪康科技药业股份有限公司生物工程中心,四川成都611731 [3]浙江省台州医院骨科,浙江台州317000 [4]安徽省红十字铜陵医院骨科,安徽铜陵244000

出　　处：《苏州大学学报（医学版）》2005年第4期595-598,共4页Suzhou University Journal of Medical Science

摘　　要：目的研究以可降解吸收的高分子材料制成的可吸收球囊的生物学性能及其用于椎体成形术治疗胸腰椎爆裂骨折的可行性。方法采用可吸收高分子材料———DL-乳酸与ε-己内酯(70∶30)的共聚物(PDLLA-CL)制造直径1.9 cm的可吸收球囊,进行体外降解试验和动物实验,观察胫骨上端回植骨块的愈合情况及球囊的吸收情况。结果可吸收球囊的初始拉伸强度为8.5 MPa,2周后为4.2 MPa,于体外24周可完全降解。载负磷酸钙骨水泥的可吸收球囊的动物实验显示,于16周时,球囊已部分吸收,胫骨上端开槽处回植骨块愈合良好,无骨膜反应和排斥反应。结论采用PDLLA-CL研制的可吸收球囊,一方面具有良好的生物相容性,对机体正常组织结构无不良影响;另一方面具备良好的机械性能,可以将灌注入内的磷酸钙骨水泥与周围组织形成一个良好的分割屏障,有效防止骨水泥的渗漏。Objective To study the biological property of absorbable balloon made from biodegradable materials and the feasibility of absorbable balloon vertebroplasty for the treatment of thoracolumbar burst fractures. Methods Absorbable balloon was produced the diameter of which was 1.9 cm, using absorbable high polymer materials PDLLA-CL made from the homoconjugate DL-lactic acid and ε-caprolactone with ratio of 70 ： 30. The in vitro degradation and animal tests were done for the sake of observing the healing results of the tibial upper end bone returned-graft and degradation of the ballon. Results The initial split strength of absorbable ballon was 8.5Mpa, and 4.2Mpa 2 weeks later. It degraded absolutely in vitro 24 weeks later. In animal test, the absorbable balloon, loaded with calcicum phosphate cement, was absorbed partly 16 weeks later. And the healing results of the tibial upper end bone returned-graft was perfect, without periosteum reaction and rejection. Conclusion The absorbable balloon made from PDLLA-CL not only has perfect biological compatibility-no harmful effects on the surrounding normal organisms and structures, but also has good mechanical function-effectively preventing leakage of the calcicum phosphate cement through as well as forming good protective screen between the calcicum phosphate cement and the local organisms.

关 键 词：可吸收球囊 椎体成形术 胸腰椎爆裂骨折 聚乳酸 聚己内酯 

分 类 号：R683.205[医药卫生—骨科学]