三碘苯酚乙基纤维素微球的制备  

Development of 2,4,6-Triiodophenol Microspheres with Ethylcellulose

作　　者：刘瑞丽[1] 姜庆军[2] 刘士远[2] 李文新[1] 

机构地区：[1]中国科学院上海应用物理研究所,上海201800 [2]第二军医大学,上海200433

出　　处：《中国科学院研究生院学报》2005年第5期575-578,共4页Journal of the Graduate School of the Chinese Academy of Sciences

摘　　要：为提高造影剂的颗粒度,减少血池造影剂透过血管壁向组织间质渗出,影响血池造影剂的造影效果,采用液中干燥法制备了三碘苯酚乙基纤维素微球,研究了三碘苯酚与乙基纤维素的质量比对微球成球性、粒径以及载药量的影响,发现两者的质量比为1∶2时成球性最好,所得微球为规整的球形,微球粒径最小,平均粒径D50为3.68μm,载药量为41.4%.In this paper,2,4,6-triiodophenol-ethylcellulose-microsphere was developed by in-liquid drying method, in order to increase the granularity of the X-ray CT contrast agent and to prevent the blood vessel X-ray CT contrast agent from exuding through the vascular wall to the tissue. The influences of the composition ratio of 2,4,6-triiodophenol： ethylcellulose to the microspheres＇ appearance and diameter, and the entrapment of 2,4,6-triiodophenol were studied. It was found that when the composition ratio was 1 ： 2, the microspheres＇ appearance was round, the average diameter was only 3.68μm, and the entrapment of 2,4,6-triiodophenol was 41.4%.

关 键 词：液中干燥法 三碘苯酚 乙基纤维素微球 血池造影剂 

分 类 号：R96[医药卫生—药理学]