TNF-α对小鼠银屑病模型的实验研究  

Experimental study of TNF -α in psoriasis model mice

作　　者：高慧[1] 王琴[1] 李瑞琴[1] 盛树青[1] 苏庆[1] 

机构地区：[1]扬州大学医学院,江苏扬州225001

出　　处：《皮肤病与性病》2005年第3期6-7,共2页Dermatology and Venereology

基　　金：扬州大学科研基金(项目编号:K9811246)资助

摘　　要：为了研究TNF-α对银屑病两种动物实验模型的作用,采用小鼠阴道上皮细胞有丝分裂模型及小鼠尾部鳞片表皮模型,以甲氨碟呤为阳性对照,评价TNF-α对细胞有丝分裂和颗粒细胞层的作用。结果显示TNF-α对小鼠阴道上皮细胞的有丝分裂、小鼠尾部鳞片表皮的颗粒层形成均无明显影响。提示TNF-α对银屑病皮损的影响是一个极及其复杂的过程。To study the effect of TNF-α on psoriasis model mice. The authors used two kinds of animal experimental models, mouse vaginal epithelium in estrus cycle and mouse tail scaled epidermis to assess the effect of TNF - α on epithelial mitosis and epidermal keratinization respectively. RESULTS There is no significant effect of TNF- α on the mitosis in mouse vaginal epithelium（P 〉 0.05）.We also found that there is no significant effect of TNF - α on formation of granular layer in scale epidermis of mouse tail（ P 〉 0.05 ）. Both above suggest that is a complex process of TNF - α in psoriasis.

关 键 词：TNF 小鼠银屑病模型 

分 类 号：R332[医药卫生—人体生理学] R758.63[医药卫生—基础医学]