三种药物对猪棘头虫LDH同工酶的抑制试验  

THE THREE MEDICINES INHIBITING THE LDH ISOENZYME OF M.HIRUDINACEUS

作　　者：廖党金[1] 官国均 

机构地区：[1]四川省畜牧兽医研究所

出　　处：《畜牧兽医学报》1996年第4期348-354,共7页ACTA VETERINARIA ET ZOOTECHNICA SINICA

摘　　要：根据猪棘头虫与宿主（猪）血清的ＬＤＨ同工酶的差异，用０．１％硝硫氰醚、０．１％丙硫咪唑和０．１％吡喹酮分别对猪棘头虫雄虫、雌虫和猪血清的ＬＤＨ同工酶进行了抑制试验，结果除硝硫氰醚对蛭形巨吻棘头虫雄虫、雌虫的ＬＤＨ同工酶有抑制作用外，其余的试验组与对照组均无差异。硝硫氰醚对雄虫ＬＤＨ同工酶的第２、３、４带和雌虫ＬＤＨ同工酶的第２、３带有不同程度的抑制作用，特别是雌虫ＬＤＨ同工酶的第２带最敏感，在０．１％的浓度下，该酶带被完全抑制，即没显示出来，硝硫氰醚对雄虫和雌虫ＬＤＨ同工酶的极弱带（它们各自的第１带）均无抑制作用；临床实验也显示出硝硫氰醚对治疗猪棘头虫病有一定疗效，这些表明硝硫氰醚抑制蛭形巨吻棘头虫的ＬＤＨ同工酶活力可能是该药物对该虫体的作用机理之一。This paper deals with a test that the LDH isoenzymes of M.hirudinaceus bodyliquid and the host serum were inhibted by 0.1% of Nitroscanate,0.1% of Albenda-zole and 0.1% of Praziquantel according to their different patterns.The results showedthat the three medicines were ineffectual on the LDH isoenzymes but Nitroscanate hadeffect on the LDH isoenzvme of the worm,It had different effects on the second, thirdand fourth LDH isoenzyme bands of the male and the second and third LDH isoenzymebands of the female,in particular the second LDH isoenzyme band of the female,which did not appear under 0.1% of Nitroscanate.But it did not have effect on thefirst LDH isoenzvme band of both the male and the fel11ale,its activities were theweakest in those LDH isoenzyme bands respectively.It had been proved by the clinicalexperiment that the medicine had effect on the pig's acanthocephaliasis.Therefore,thisis one of the mechanisms of Nitroscanate against M.hirudinaceus.

关 键 词：同功酶 棘头虫 硝硫氰醚 吡喹酮 丙硫咪唑 猪病 

分 类 号：S858.285.9[农业科学—临床兽医学] S859.795[农业科学—兽医学]