麻黄汤不同配伍对大鼠发汗作用的影响  

Effects of Mahuang Decoction in Different Combinations on Diaphoretic Function in Rats

作　　者：刘国清[1] 罗佳波[1] 

机构地区：[1]南方医科大学中医系中药新药研究实验室,广州510515

出　　处：《中药新药与临床药理》2005年第5期318-320,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金重点资助项目(编号30030150)

摘　　要：目的研究麻黄汤不同配伍对大鼠的发汗作用。方法采用组织形态学方法,以大鼠腋窝部皮肤汗腺的空泡发生百分率作为评价发汗强度的指标,观察麻黄汤不同配伍给药后30 min对大鼠的发汗作用。结果麻黄+桂枝组发汗作用最强,含麻黄的各配伍组其发汗作用均强于不含麻黄的配伍组;配伍桂枝后发汗作用增强;配伍杏仁后各配伍组的发汗作用没有明显变化;配伍甘草后发汗作用减弱。结论麻黄、桂枝、杏仁、甘草在麻黄汤中分别起到君臣佐使的作用,深刻体现了组方规律。Objective To study the influence of Mahuang Decoction （MD） in different combinations on diaphoretic function in rats. Methods Vacuole incidence of axillary sweat gland was determined by observing the histolomorphological changes of vacuole to evaluate the diaphoretic function. The diaphoretic function was observed in 30 minutes after administration. Results The combination of Mahuang （Herba Ephedrae） and Guizhi （Ramulus Cinnamomi） had the strongest diaphoretic function in all of the different combinations. The diaphoretic function of the combinations including Mahuang （Herba Ephedrae） was stronger than those excluding Mahuang （Herba Ephedrae） . The diaphoretic function of Mahuang （Herba Ephedrae） became stronger when used together with Guizhi （Ramulus Cinnamomi）, remained the same when used together with Xingren （Semen Armeniacea Amarum）, and became weaker when used together with Gancao （Radix Glycyrrhizac） . Conclusion Mahuang （Herba Ephedrae）, Guizhi （Ramulus Cinnamomi）, Xingren （Semen Armeniacea Amarum）, and Gancao （Radix Glyeyrrhizac） play the roles of principle drug, assistant drug, adjuvant drug and conductantr drug respectively in Mahuang Decoction, which embodying the method of composing a prescription.

关 键 词：麻黄汤 配伍规律 发汗 汗腺 空泡 

分 类 号：R285.5[医药卫生—中药学]