晕康胶囊的药效学研究  

Pharmacodynamic Study of Yunkang Capsule

作　　者：李作孝[1] 肖顺汉[2] 杨思进[2] 唐灿[2] 张仕善[3] 

机构地区：[1]泸州医学院附属医院神经内科,四川泸州646000 [2]泸州医学院药学院,四川泸州646000 [3]泸州医学院附属医院药研所,四川泸州646000

出　　处：《中药新药与临床药理》2005年第5期333-336,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：四川省教育厅资助课题(编号01LA39)

摘　　要：目的探讨晕康胶囊(YKC)的药效学作用。方法将大鼠或小鼠分为晕康胶囊大中小剂量组、地芬尼多及模型和空白对照组,分别对YKC抗晕动作用、血栓形成、血液流变学、软脑膜微循环、自由基的变化进行观察。结果晕康胶囊能明显延长晕动潜伏期,能显著降低血栓湿重、全血粘度、血浆粘度、红细胞压积,能明显扩张软脑膜微血管、增加交织网点数目,能明显升高血浆SOD活性、降低血浆MDA含量。结论晕康胶囊具有抗晕动、抑制血栓形成、改善血液流变及微循环、清除氧自由基的作用。Objective To investigate the pharmacodynamic action of Yunkang Capsule （YKC） . Methods The animals were divided into YKC groups （at high-, moderate- and low-dosage respectively）, diphenidol control group, model control group and blank control group. The action of YKC on vertigo and thrombosis, hemorrheologic indexes, piamatral microcirculation and free radicals of the animal models were observed. Results YKC could significantly prolong the latency of vertigo, reduce wet weight of thrombus, decrease blood viscosity, plasma viscosity and hematocrit, promote the dilation of piamatral micro-vessels, increase the amount of interweave microdot, increase plasma SOD activity and decline plasma MDA content of animal models. Conclusion YKC has actions of counteracting vertigo and thrombosis, improving hemorrheology and microcirculation, and clearing away free radicals.

关 键 词：晕康胶囊 药效学试验 眩晕 

分 类 号：R285.5[医药卫生—中药学]