HBIG阻断乙型肝炎母婴传播的临床观察  

The application of HBIG blocking hepatitis B virus infection from mot her to infant

作　　者：牛新海 严维高 

机构地区：[1]镇江丹徒区人民医院,江苏镇江212003

出　　处：《现代医药卫生》2005年第20期2734-2736,共3页Journal of Modern Medicine & Health

摘　　要：目的:探讨高效价乙肝免疫球蛋白(HBIG)阻断乙型肝炎病毒(HBV)母婴传播的作用机理。方法:将93例HBsAg阳性的孕妇随机分成两组,实验组孕妇临产前三个月,每月注射一针HBIG(200IU),共3针,接种后无局部及全身不良反应;对照组不用HBIG。两组孕妇所生婴儿均于出生后4小时内肌肉注射HBIG 100IU 1次,注射乙肝疫苗的时间和剂量均按正常婴儿的操作方案进行,母儿血清HBsAg和抗-HBs用酶免法检测,HBV-DNA用定量PCR检测。结果:实验组婴儿血清HBsAg和HBV-DNA检出率明显低于对照组(P<0.05);抗-HBs阳性率显著高于对照组(P<0.05),实验组阻断效果可达94.7%。结论:孕妇于孕晚期联合应用HBIG和乙肝疫苗进行主、被动免疫,可有效地阻断乙型肝炎病毒母婴传播,降低婴儿HBV感染率。Objective： To explore the effect of hepatitis B immunoglobulin （HBIG） blocking hepatitis B vires （HBV） infection from mother to infant.Methods：93 pregnant women were randomly divided into two groups： the test group was injected with HBIG （200IU） three months before delivery（once each month,totel in three times）; the control group was not treated with HBIG.The infants of two groups were injected with HBIG （100IU） after 4 hours of birth and got the hepatitis B vaccine with the time and doses as general way.The HBsAg and HBsAb were detected by ELISA and the HBV-DNA was analyzed with PCR in both of the mothers and infants.Results：The HBsAg and HBV-DNA were found very low in test group infants compared with those in control group （P〈0.05）;While the HBsAb was strongly high in test group compared with that in control group（P〈0.05）,the blocking rate was high to 94.5%.Conclusion：The Combined application of HBIG and HBV vaccine to pregnant women may effectively prevent the infection of hepatitis B virus from the mother to infant.

关 键 词：HBIG 母婴垂直传播 阻断 HBV 

分 类 号：R5[医药卫生—内科学]