两种巴布剂基质的体外经皮渗透性考察  

Skin Penetration Property of Drugs in Two Cataplasma Carriers

作　　者：彭丽华[1] 刘淑芝[1] 郭春燕[1] 李曼玲[1] 冯伟红[1] 康琛[1] 金日显[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2005年第5期1-3,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的对所制备的中药巴布剂进行透皮吸收实验研究。方法采用改进的透皮扩散试验仪进行经皮渗透实验,经高效液相测定吴茱萸所含吴茱萸碱、吴茱萸次碱在一定时间的经皮累积透过量,并进一步考察两种巴布剂基质的经皮渗透规律。Objectives： To compare the releasing rates in vitro of evodiamine and rutaecarpine in two kinds of cataplasma carriers. Methods： The releasing of evodiamine and rutaecarpine from the cataplasma carriers in vitro were measured, imitating the method of percutaneous absorption by using improved Franz＇S diffusion cell and HPLC. Results ： The releasing rates of Evodiamine and rutaecarpine in the carrier made of acrylic resin copotymer and natural copolymers are higher than those in the carrier made of acrylic resin coDolymer and compounded copolymers. And both the releasing processes fit to the Higuchi equation. Conclusion：Both the cataplasma carriers have good drug releasing properties.

关 键 词：透皮吸收 巴布剂 吴茱萸碱 吴茱萸次碱 高效液相色谱法 

分 类 号：R283.6[医药卫生—中药学]