咳喘平与病毒唑联合应用体外对呼吸道合胞病毒抑制作用的研究  

In vitro inhibition of respiratory syncytial virus with combined ribavirin and kechuanping

作　　者：叶卉初[1] 刘玉华[1] 侯安存[1] 赵高潮[2] 王凤莲[2] 乌珊娜[2] 

机构地区：[1]首都医科大学附属北京友谊医院儿科,北京100050 [2]北京热带医学研究所,北京100050

出　　处：《临床和实验医学杂志》2005年第3期147-149,共3页Journal of Clinical and Experimental Medicine

基　　金：中医局资助的重点扶植科室的研究项目。

摘　　要：目的了解咳喘平、病毒唑及二者联合应用时对呼吸道合胞病毒(RSV)的体外抑制作用。方法观察不同药物浓度下RSV对Hep-2细胞的致病作用。结果病毒唑完全抑制RSV复制的最小浓度为7·8μg/ml,咳喘平为13·75mg/ml,两药联合应用时,病毒唑和咳喘平完全抑制RSV的最小浓度分别减少到1·95μg/ml和3·44mg/ml,比单独用药浓度降低了4倍。结论两种药物对RSV都有体外抑制作用,联合应用时效果最强。Objective To study the anti-virus effect of combination of ribavirin with kechuanping on respiratory syncytial virus （RSV） in vitro. Methods Cytopathic effect （CPE） of RSV to Hep-2 cells in different concentration of ribavifin, kechuanping and combination of ribavirin with kechuanping was observed. Results The minimum concentrations of ribavirin and kechuanping were respectively 7.8μg/ml and 13.75mg/ml for inhibiting completely the proliferation of RSV. When the combination of ribavirin with keehuanping was used, tthe concentrafions were respectively decreased to 1.95μg/ml and 3.44mg/ml. Condusion Both ribavirin and kechuanping showed anti-RSV effect in vitro, but tile inhibitory effect of combined ribavirin and kechuanping was more potent than either of the preparation alone.

关 键 词：咳喘平 病毒唑 中草药 呼吸道合胞病毒 

分 类 号：R725.6[医药卫生—儿科]