婴幼儿对乙型病毒性肝炎基因工程疫苗免疫反应调查  

AN INVESTIGATION OF IMMUNO REACTION IN YOUNG CHILDREN TO HEPATITIS B VIRUS GENETIC ENGINEERING VACCINES

作　　者：谢桂芹[1] 元红[1] 孙凯燕[1] 

机构地区：[1]青岛市市北区妇幼保健所,山东青岛266021

出　　处：《青岛大学医学院学报》2005年第4期347-347,349,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的了解青岛地区婴幼儿对乙型病毒性肝炎基因工程疫苗的免疫反应。②方法以整群随机抽样方法对1岁儿童200例、2岁儿童200例、3岁儿童206例乙型病毒性肝炎病毒表面抗体进行调查。③结果1岁内婴儿乙型病毒性肝炎病毒表面抗体阳性率为78%,阴性率为19%,弱阳性率为3%;2岁内婴儿乙型病毒性肝炎病毒表面抗体阳性率为24%,阴性率为65%,弱阳性率为11%;3岁幼儿阳性率为22%,阴性率为78%,弱阳性率为0。1岁内婴儿乙型病毒性肝炎病毒表面抗体阳性率与2岁、3岁幼儿比较差异有显著性(uc=7.39、8.17,P<0.01)。④结论应该在婴幼儿2岁左右普遍检测乙型病毒性肝炎病毒表面抗体。若乙型病毒性肝炎病毒表面抗体阴性,应及时接种全程乙型病毒性肝炎基因工程疫苗。Objective To investigate the immunoreaction of young children to hepatitis B virus genetic engineering vaccines in Qingdao region. Methods An overall random sampling was used in the investigation of 1-year-old （n=200）, 2-year-old （200） and 3-year-old （206） children. Results The positive rate. negative rate and weak positive rate were; 1-year-old children, 78%, 19%, and 3%; 2-year-old children, 24%, 65% and 11%; 3-year-old children, 22%, 78%, and 0, respectively. The difference between the positive rate of the 1-year-old children and those of the 2-year-old and 3-year-old was significant （uc = 7.39,8. 17; P〈0.01 ）. Conclusion A survey of HBsAB should be conducted in children at around two years old. If HBsAB is negative, then hepatitis B virus genetic engineering vaccines be inoculated.

关 键 词：肝炎疫苗 乙型 肝炎抗体 乙型 儿童 

分 类 号：R186[医药卫生—流行病学]