特异性COX-2抑制剂对代偿性心脏增大大鼠炎症标记物的影响  

Inflammation Marker in Rats with Pressure Overloaded Hypertrophic Myocardium and the Influence of Selective Cyclooxygenase-2 inhibitor

作　　者：梁子敬[1] 曾量波[1] 叶政[1] 陈国勤[1] 王鹏鲲[1] 卢敏俊[1] 

机构地区：[1]广州医学院第一附属医院急诊科,510120

出　　处：《岭南急诊医学杂志》2005年第3期161-162,182,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:观察代偿性心脏增大大鼠心肌肥厚过程中各种炎症反应标记物的动态变化及特异性环氧化酶-2抑制剂的影响。方法:随机将大鼠分空白组、模型组、治疗组(第16周开始用rofecoxib),其中模型组和治疗组采用腹主动脉缩窄致压力负荷性心肌肥厚大鼠模型。在第7、12、20周检测左室质量指数(LVMI)和炎症标志物TNF- α、IL6、IL-10、TGF-β、CRP及UA水平。结果:模型组TNF-α、IL-10升高(P<0.05),治疗组均下降(分别P<0.05、P <0.01)。治疗组TGF-β明显降低(P<0.01)。结论:炎症参与了压力负荷性心肌肥厚过程。特异性环氧化酶-2抑制剂可能有抗细胞因子的作用。Objective： To investigate the change of inflammation marker in the development of rats with pressure overloaded hypertrophy myoeardium and influence of selective cyclooxygenase-2 inhibitor. Methods：39 male SD rats were randomly divided into 3 groups： sham operated group（n=16）,operated group（n=17） and treatment group （n=6）. Hypertrophy myoeardium was indued by gradually constricting the abdominal aorta in rats. 16 weeks later, treatment group was treated with rofecoxib, a selective COX-2 inhibitor （20 mg·kg^-1-d^-1 in drinking water for 4 weeks. Serum levels of TNF-α,IL-6,IL-10,TGF-β,CRP were measured by ELISA and uric acid was also measured at 7,12 and 20 weeks after operation respectively. Results：In comparison to sham operated group, TNF-α in operated group increased at 20 weeks after operation,but treatment group decreased at 20 weeks. Levels of IL-10 in operated group were increased at 20 weeks compared with group S. IL-10 in treatment gro：ap reduced compared with sham-operated group and operated group. TGF-β in treatment group were significantly lower than those of sham operated group and operated group. Conclusions：Inflammation was involved in the development of myocardial hypertrophy. The selective COX-2 inhibitor may prevent myocardial fibrosis in pressure overload model.

关 键 词：压力负荷 心肌肥厚 特异性环氧化酶-2抑制剂 细胞因子 特异性COX-2抑制剂 大鼠模型 炎症标记物 心脏增大 代偿性 炎症反应标记物 

分 类 号：R96[医药卫生—药理学]