老年男性2型糖尿病患者性激素变化4年随访  

THE CHANGES OF SEX HORMONES IN AGED MEN WITH TYPE 2 DIABETES WITH 4 YEARS'S FOLLOW-UP

作　　者：汪幸思[1] 张蓉[1] 夏俊[1] 孙皎[1] 陈芳[1] 尤传一[1] 

机构地区：[1]华东医院内分泌科,上海市200040

出　　处：《老年医学与保健》2005年第3期156-159,共4页Geriatrics & Health Care

摘　　要：目的探讨老年男性2型糖尿病患者性激素水平的变化。方法分析2000年及2004年住本院有完整病史资料的老年男性糖尿病患者,在4年中性激素水平的变化,并与同期住院的无糖尿病病史老年患者进行比较。两组患者均排除原发性急慢性肝肾疾病、急慢性感染、免疫系统疾病以及恶性肿瘤等疾病。结果2000年,糖尿病组血清睾酮(T),雌二醇(E2)、促黄体生成素(LH)和促卵泡生成素(FSH)水平分别为14.75±6.60nmol/L,203.95±109.90pmol/L,11.15±6.07U/L和23.09±13.81U/L。非糖尿病组为17.33±6.76nmol/L,162.84±95.43pmol/L,8.99±5.33U/L和18.04±9.50U/L。2004年,糖尿病组性激素水平为12.08±6.31nmol/L,264.62±124.19pmol/L,13.44±6.54U/L和25.99±13.30U/L;非糖尿病组为18.06±7.30nmol/L,167.71±78.09pmol/L,9.57±6.12U/L和18.20±9.49U/L。2000年与2004年比较,糖尿病组血清T水平下降,E2、LH和FSH水平均升高,存在统计学差异。非糖尿病组2000年与2004年比较,血清T、E2、LH和FSH均无显著性差异。两组比较,2000年糖尿病组较非糖尿病组,血清T水平下降,E2、LH和FSH均升高,有显著性差异;四年以后,两组患者的性激素水平差异更为显著。2000年和2004年,糖尿病组中血糖控制者的血清T水平均较控制不良者低,而E2、LH和FSH均无显著性差异。结论老年男性2型糖尿病患者存在性激素水平紊乱,并随着病程的延长有加剧的趋势。Objective To study the changes of sex hormones in aged men with type 2 diabetes. Methods A retrospective analysis was conducted in 62 elderly patients with type 2 diabetes who were admitted into our hospital at 2000 and 2004 （range 69 to 90 years old, 79.57 ± 4.00） Serum levels of sexual hormones in 62 aged diabetic men were determined, 50 elderly patients with other diseases but without diabetes were used as control.（range 61 to 90 01d,79.55 ± 5.44）. Results At 2000, the serum levels of testosterone（T）, estrdiol（E2）, luteinizing hormone（LH） and follicular stimulating hormone（FSH） were 14.75 ± 6.60nmol/L, 203.95 ± 109.90pmol/L, 11.15 ± 6.07 U/L and 23.09 ± 13.81 U/L respectively in the diabetic group those were 17.33 ± 6.76 nmol/L, 162.84 ± 95A3pmol/L, 8.99 ± 5.33U/L and 18.04 ± 9.50 U/L respectively in the nondiabetic group.The level of T in diabetic group was significantly lower than that in the control. And the level of E2 and FSH and LH were significantly higher in diabetic group. After four years, the mean values of T,E2,LH and FSH in diabetic group were 12.08 ± 6.31 nmol/L, 264.62 ± 124.19 pmol/L, 13.44± 6.54 U/L and 25.99 ± 13.30 U/L respectively, with 18.06 ± 7.30 nmol/L, 167.71 ± 78.09 pmol/L, 9.57 ± 6.12 U/L and 18.20 ± 9.49 U/I. for nondiabetic group. T levels in diabetic men at 2004 were significantly lower than those at 2000. on the other hand, the levels of E2, FSH and LH were significantly higher than those at 2000. There was statistical significance for differentiation in diabetic group after four years. No significant difference of sex hormone serum levels could be observed between 2000 and 2004 in diabetic men. After four years, the difference of sex hormones between these two groups became remarkable. In diabetic group, the level of T with good blood sugar control was higher than those with blood sugar poor control. No other significant difference could be observed. Conclusions There is excreting dysfunction,of sex hormones in oht men with type 2 diabet

关 键 词：老年人 糖尿病 2型 性腺激素类 随访研究 

分 类 号：R587.1[医药卫生—内分泌]