兔腹主动脉粥样硬化模型的建立  

Establishment of Rabbit Model of Atheromatous Abdomial Aorta

作　　者：蒋明东[1] 彭志平[2] 尹晓玲[3] 李少林[3] 

机构地区：[1]重庆市第九人民医院肿瘤放疗中心,重庆400016 [2]重医附属一院核医学科,重庆400016 [3]重庆医科大学核医学教研室,重庆400016

出　　处：《动物医学进展》2005年第9期46-49,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金资助(30171060)

摘　　要：为建立兔腹主动脉粥样硬化模型,将60只新西兰大耳白兔随机分为高脂饲料和普通饲料两组喂养每组30只,定期测量体重和血脂类指标,18周处死动物,观察腹主动脉形态结构。结果表明,高脂饲料兔血脂类指标升高,血管内壁脂质沉积,镜下见内皮细胞脱落缺失,多层泡沫细胞堆积,平滑肌细胞减少或增生,弹力蛋白和胶原糖蛋白基质成分增多等改变,表明动物模型建立成功。In order to establish rabbit model of atherosclerotic abdominal aorta, we made sixty big New Zealand rabbits into two grades： first grade （n=30） was fed with high fat food, second grade （n=30） with common food. We regularly measured index of body weight and serumlipid of rabbits. After 18 weeks, we executed the animals for analyzing and observing shapes and structures of abdominal aorta. The results of first grade were that the index of serumlipid rised and lipide aggradated inside blood vessel wall of abdominal aorta. We found a lot of changes by microscope, for example, endothelial cells sheded or gone without, foam cells were piled up, smooth muscle cells decreased or multiplicate, elasticprotein and collagen glycoprotein increased and so on. All together indicated that we had successfully constructed rabbit animal model.

关 键 词：兔 动脉粥样硬化 腹主动脉 高脂饲料 模型 

分 类 号：S852.3[农业科学—基础兽医学]