复方酒剂中乌头碱含量的测定及其中毒剂量的研究  

Determination of Aconitine in Medicinal Wine and Its Dosage of Aconitine Poisoning

作　　者：张宏桂[1] 马辰[2] 巫毅[3] 刘爱茹[2] 张寒琦[1] 

机构地区：[1]吉林大学化学学院,长春130012 [2]中国医学科学院药物研究所,北京100050 [3]吉林大学第二医院,长春130041

出　　处：《吉林大学学报（理学版）》2005年第5期677-679,共3页Journal of Jilin University:Science Edition

基　　金：国家自然科学基金(批准号:39870874)

摘　　要：用一种改进的高效液相色谱方法测定了具有高毒性药酒中乌头碱的含量,基于测定结果确定了该药酒的中毒剂量.同时揭示了该酒剂乌头碱中毒的化学原因.A modified HPLC method was used for the separation and the determination of aconitum alkaloids in medicine wine. The toxieal dosages of the preparations were established on the basis of the data from the above determination. At the same time, the chemical reasons of aeonitine poisoning were revealed. These reasons have provided some scientific bases for the clinical safe drug use.

关 键 词：乌头碱 中毒剂量 高效液相色谱法 

分 类 号：O657[理学—分析化学]