大蒜提取液抑制人结肠癌细胞SW480和SW620的增殖和扩散  

Restraint of Proliferation and Spreading of Human Colorectal Cancer Cells SW480 and SW620 by Aqueous Extract of Garlic

作　　者：李招发[1] 徐雪松[2] 孙立文[1] 申兴桂[1] 庄妍[1] 赵志壮[1] 李青山[1] 付学奇[1] 

机构地区：[1]吉林大学生命科学学院Edmond H Fischer细胞信号传导实验室,长春130021 [2]吉林大学中日联谊医院,长春130031

出　　处：《吉林大学学报（理学版）》2005年第5期687-690,共4页Journal of Jilin University:Science Edition

基　　金：国家自然科学基金(批准号:30470391);吉林大学创新基金(批准号:450011022055)

摘　　要：研究了天然大蒜提取液对人结肠癌细胞SW 480和SW 620的扩散、粘附和增殖的影响.结果表明:将SW 480和SW 620加入1μL/孔大蒜提取液的DMEM中,癌细胞扩散率降低了40%;培养96 h,增殖率分别降低8.6倍和10.8倍.表明大蒜提取液能抑制人结肠癌细胞SW 480和SW 620的增殖和扩散.The effects of aqueous extract from garlic on spreading, adhesion and proliferation of human colorectal cancer cells SW480 and SW620 were tested. The results show the spreading ratios of both SW480 and SW620 cells are reduced 40%, proliferation ratios of SW480 and SW620 which were cultured for 96 h in DMEM containing 1 μL/well aqueous extract from garlic are reduced 8.6 and 10. 8 times than that of control. The experiment indicateted that aqueous extract from colorectal cancer cells SW480 and SW620. garlic restrained proliferation and spreading of human colorectal cancer cells SW480 and SW620.

关 键 词：大蒜 癌细胞SW480 癌细胞SW620 增殖和扩散 

分 类 号：Q227[生物学—细胞生物学]