血脂吸附剂的合成及吸附性能研究  

Blood lipid adsorption of polyethylene glycol/montmorillonite nanocomposite

作　　者：莫建坤[1] 邱玉超[2] 韦莉萍[2] 谢少玉[2] 兰萌[3] 雷达[1] 徐耿明[2] 

机构地区：[1]广东省第二人民医院检验科,广东广州510317 [2]南方医科大学南校区,广东广州510315 [3]南方医科大学珠江医院,广东广州510311

出　　处：《第一军医大学学报》2005年第9期1161-1163,共3页Journal of First Military Medical University

基　　金：广州市科技攻关课题资助项目(2004Z3-E0171)~~

摘　　要：目的合成纳米复合材料作为吸附剂,并检测其吸附效果。方法制备聚乙二醇(PEG)/蒙脱石(MMT)纳米复合材料,采用X-射线衍射分析PEG/MMT插层复合物的结构;应用合成的纳米复合材料做血脂和血清蛋白吸附实验。结果较大相对分子质量的PEG与MMT插层后的层间距更大。PEG/MMT纳米复合材料对血清中的甘油三脂、总胆固醇、低密度脂蛋白胆固醇吸附性强,对血清中白蛋白的吸附性能相对较弱,而MMT吸附性能差。结论PEG/MMT纳米复合材料可以进一步开发为血脂吸附材料。Objective To evaluate the effect of polyethylene glycol/montmorillonite （PEG/MMT） nanocomposite material in adsorption of triglyceride （TG）, cholesterin and low-density lipoprotein-cholesterol （LDL-C）. Methods The structure of PEG/MMT nanocomposite was analyzed by means of X ray diffraction and its effect of blood lipid and albumin adsorption was evaluated in comparison with Na-MMT. Results The interval distance was larger when the PEG of greater molecular weight was used for preparing the nanocomposite, and PEG/MMT nanocomposite had greater adsorption rate of TG, cholesterin and LDL-C in serum than that of serum albumin. MMT material had poor adsorption effect. Conclusion PEG/MMT nanocomposite possesses the potential as a novel adsorbent of blood lipid for clinical use.

关 键 词：纳米技术 吸附剂 蒙脱石 聚乙二醇 血脂 白蛋白 

分 类 号：R318.08[医药卫生—生物医学工程]