常通口服液对兔术后肠粘连的预防作用  

Prevention Action of Changtong Oral Liquid on Postoperative Intestinal Adhesions in Rabbits

作　　者：王春霞[1] 侯连兵[1] 

机构地区：[1]南方医科大学南方医院药学部,广州510515

出　　处：《中华中医药杂志》2005年第7期395-396,共2页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点科技攻关项目(No:9690105245)

摘　　要：目的观察常通口服液对兔术后肠粘连的预防作用。方法选取36只雄性新西兰白兔随机分为6组(n=6)。除正常对照组外,其余各组均制成肠粘连模型。正常对照组及模型对照组予以蒸馏水灌胃(20ml/kg);四磨汤组以10ml/kg灌胃给药;常通口服液低、中、高剂量组分别按2.15、4.30、8.60g/kg剂量灌胃给药。术后第3天兔耳缘静脉取血,测定血浆中组织型纤溶酶原激活物(tPA)及其抑制因子(PAI1)活性;术后第9天进行粘连程度肉眼分级。结果常通口服液能明显减轻肠粘连的程度,增加肠粘连兔血浆中tPA活性,而抑制PAI1活性。结论常通口服液能够预防术后肠粘连形成。Objective: To observe the Prevention Action of Changtong Oral Liquid (CTOL) on the postoperative intestinal adhesions in rabbits. Method: Thirty-six male New Zealand rabbits were randomly divided into six equal groups (n=6): Normal control (group 1); model control (group 2); Simo Decoction (group 3); and CTOL minimal, medium and maximal dosages (group 4,5,6). Except group 1, the other rabbits were created as intestinal adhesive models. Group 1 and group 2 were orally fed with distilled water (20ml/kg), and group 3 to 6 with Simo Decoction 10ml/kg and CTOL in doses of 2.15g/kg, 4.30g/kg and 8.60g/kg respectively. On day 3 after surgery, the blood samples were collected to determine the fibrinolytic activity, and on day 9 the adhesion was graded. Result: CTOL could evidently reduce the severity of postoperative adhesions and increase plasma tPA activity and inhibit plasma PAI-1 activity. Conclusion: CTOL could prevent postoperative intestinal adhesion formation.

关 键 词：常通口服液 肠粘连 纤溶酶原激活物 纤溶酶原激活物抑制因子 实验研究 术后肠粘连 新西兰白兔 预防作用 组织型纤溶酶原激活物 正常对照组 

分 类 号：R285.5[医药卫生—中药学]