鹅不食草挥发油对急性肺损伤大鼠支气管上皮细胞CD54表达的影响  

Effects of the Volatile Oil of Sandwort on Expression of CD54 in the Bronchial Epithelium Tissue of Acute Lung Injury Rat

作　　者：覃仁安[1] 师晶丽[2] 宛蕾[3] 梅璇[1] 姚丽君[3] 沈映君[4] 

机构地区：[1]贵阳医学院附属医院药剂科,贵阳550004 [2]中山大学第五附属医院中医科,珠海519000 [3]贵阳医学院药理教研室,贵阳550004 [4]成都中医药大学,成都610075

出　　处：《中华中医药杂志》2005年第8期466-468,452,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：贵州省科委科学基金项目(20002)

摘　　要：目的:研究鹅不食草挥发油的抗炎作用及其可能的机制。方法:采用油酸合并脂多糖“两次打击”致大鼠急性肺损伤模型,观察鹅不食草挥发油对大鼠急性肺损伤的保护作用。结果:鹅不食草挥发油能显著抑制急性肺损伤所致大鼠肺水肿及中性粒细胞升高,抑制肺损伤大鼠支气管上皮细胞中CD54的表达。结论:鹅不食草挥发油对大鼠急性肺损伤有明显的保护作用,减少支气管上皮细胞CD54的表达是其抗吸呼道炎症作用的可能机制。Objective: To study the anti-inflamation effect of Volatile oil of Centipesa minima and the mechanism of action. Method: The “Two-hit” animal model of acute lung injury in rats was induced by oleic acid and lipopolysaccharide, to observe the protective effect of VOCM on acute lung injury in rats. Result: VOCM was able to suppress lung edema and high numbers of neutrophils, decrease the expression of CD54 in the bronchial epithelium tissue in the acute lung injury animal models. Conclusion: VOCM has a protective effect on acute lung injury in rats. Decreasing the expression of CD54 in the bronchial epithelium tissue may be one of its mechanisms of against respiratory tract inflammation.

关 键 词：鹅不食草挥发油 抗炎机理 细胞间黏附分子-1 实验研究 急性肺损伤模型 支气管上皮细胞 CD54表达 鹅不食草 挥发油 大鼠 

分 类 号：R285.5[医药卫生—中药学]