复方芪参降脂饮对高胆固醇血症大鼠主动脉壁细胞间黏附分子-1表达量的影响  

Influence of complex prescription Qishenjiangzhiyin on expressions of intercelluar adhesion molecule-1 in the aorta of hypercholesteremia rats

作　　者：李佃淳[1] 张红[1] 张福海[2] 王德谦 

机构地区：[1]大连医科大学附属第二医院中医科,大连116027 [2]大连医科大学附属第二医院药剂科,大连116027 [3]辽宁铁法疗养院,铁法112700

出　　处：《中国临床药学杂志》2005年第5期282-284,共3页Chinese Journal of Clinical Pharmacy

基　　金：辽宁省教育厅科学研究计划资助(编号:202203250)

摘　　要：目的观察复方芪参降脂饮对实验性高胆固醇血症大鼠主动脉壁细胞间黏附分子-1(ICAM-1)表达的影响。方法24只SD大鼠随机分为3组,每组8只。对照组喂以普通饲料;模型组喂以高脂饲料;中药组喂以高脂饲料,同时给予复方芪参降脂饮15 mL.kg-1,ig,qd。6 wk后处死,取血测血脂;用免疫组化法检测主动脉壁ICAM-1表达水平。结果中药组大鼠血清胆固醇水平明显低于模型组(P<0.05),主动脉壁ICAM-1表达量明显低于模型组(P<0.01)。结论复方芪参降脂饮能够降低实验性高胆固醇血症大鼠血脂,抑制ICAM-1在主动脉壁的表达。AIM To observe the effect of complex prescription Qishenjiangzhiyin on intercellular adhesion molecule-1 （ICAM-1） in the aorta of hypercholesterolemic rats. METHODS Twenty-four male SD rats were randomly and equally divided into three groups ： control group, model group and treatment group. Rats of control group were fed with normal diet. Rats of model group were fed with high cholesterol diet. Rats of treatment group were fed with high cholesterol diet plus complex prescription Qishenjiangzhiyin. After 6 wk, all the rats was killed. Serum cholesterol level was measured. The ICAM-1 expression of aorta was measured by immunohistochemistry. RESULTS The level of serum cholesterol decreased significantly as compared with that of model group（ P 〈 0.05）. ICAM-1 expression level of aortas in treatment group was significantly lower than that in model group （ P 〈 0.01 ）. CONCLUSION The complex prescription Qishenjiangzhiyin can reduce serum cholesterol and inhibit the expression of ICAM-1 in aorta.

关 键 词：高胆固醇血症 动脉粥样硬化 复方芪参降脂饮 细胞间黏附分子-1 

分 类 号：R285[医药卫生—中药学]