胰岛素对成人晚发自身免疫性糖尿病患者C肽水平的影响  

Effects of insulin on the level of C peptide in patients with latent autoimmune diabetes mellitus in adults

作　　者：许桂菊[1] 赵晓春[1] 王雪琴[1] 

机构地区：[1]山西省大同市第五人民医院干二科,大同037006

出　　处：《中国临床药学杂志》2005年第5期307-309,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的观察胰岛素对成人晚发自身免疫性糖尿病(LADA)患者C肽水平的影响。方法LADA患者87例分为2组,A组以口服降糖药物治疗,B组以胰岛素治疗,血糖控制在良好水平[糖化血红蛋白(HbA1c)≤7%],每隔6 mo抽血测0、60、120和180 min C肽水平,计算C肽面积,共观察2 a。结果A、B 2组2 a后分别完成观察46例和32例,A组患者C肽面积于2 a时缓慢下降,B组一直保持治疗前水平,2组比较差异有显著性意义(P<0.05)。结论LADA患者早期采用胰岛素治疗,可有效保持C肽面积,保护胰岛功能。A/M To observe the offects of insulin on the level of C-peptide of untreated patients with latent autoimmune diabetes in adults （LADA）. METHODS Eighty-seven patients of LADA were divided into mainly lower-bloodglucose oral medicine therapy group（ Group A）, mainly insulin therapy group（Group B） and the treatment result was HbAlc≤7% .The level of C-peptide of blood （0, 60, 120, and 180 rain） was tested every half a year. The area of C- peptide was calculated. RESULTS The level of C-peptide of group A decreased slowly in secend year while group B remained the level before theatment. The difference between the two groups was significant（ P 〈 0.05 ）. CONCLUSION The earlier insulin therapy can prevent the level of C-peptide from decreasing and protect insulin function in LADA.

关 键 词：胰岛素治疗 成人晚发自身免疫性糖尿病 C肽 

分 类 号：R587.1[医药卫生—内分泌]