参附注射液对体外循环期间胃肠灌注及氧合的影响  

Effect of shen-fu on gastrointestinal perfusion and oxgenation during cardio-pulmonary bapass

作　　者：詹丽英[1] 夏中元[1] 夏芳[1] 刘先义[1] 

机构地区：[1]武汉大学人民医院麻醉科,湖北武汉430060

出　　处：《中国现代医学杂志》2005年第18期2814-2816,共3页China Journal of Modern Medicine

摘　　要：目的观察参附注射液(SF)对体外循环期间胃黏膜pH值(pHi)、内毒素血症及全身炎性反应的影响。方法选择临床心内直视手术患者60例,随机分为对照组和SF组,SF组于切皮时静注SF0.5mL/kg,再取1.0mL/kg从Grasby泵注入,对照组则输入等量生理盐水。分别于于切皮前(S0)、主动脉开放1h(R1)、2h(R2)后测定胃黏膜pH值(pHi)、血浆内毒素(LPS)、及白介素(IL-6)水平。结果两组R1和R2时,pHi值显著低于S(0均P<0.01)、LPS和IL-6显著高于S(0均P<0.01);SF组R1和R2时pHi值显著高于对照组(均P<0.01),LPS和IL-6显著低于对照组(均P<0.01)。结论SF通过改善体外循环期间胃肠灌注及氧合,减轻内毒素血症及全身炎性反应。[Objective] To investigate the effect of shen-fu on gastrointestinal intramucosal pH（pHi）, endotoxemia and systemic inflammatory during cardio-pulmonary bypass. [Methods] 60 patients undergoing elective heart surgery were divided into control group and SF group randomly. Before CPB, The SF group was treated with SF 0.5 mL/kg by intravenous injection, then continued with SF1.0 mL/kg injected from Grasby pump, The control group was injected with normal saline in equal volume. Intramucosal pH value （pHi）, blood LPS and IL-6 were measured before CPB, 1 h after artery was opened, 2 h after artery was opened. [Results] In both groups pHi at R1, R2 was lower than that at So significantly （both P 〈0.01）. Blood LPS, blood IL-6 at R1. R2 were higher than those at So significantly （both P 〈0.01 ）. In SF group, pHi at R1. R2 was higer than that in control group significantly （both P 〈0.01 ）, Blood LPS, blood IL-6 at R1. R2 were lower than those in control group significantly （both P〈0.01）. [Conclusion] SF can improve gastrointestinal perfusion and oxygenation, then reduce endotoxemia and systemic inflammatory during cardio-pulmonary bypass.

关 键 词：参附注射液 体外循环 胃肠道 灌注和氧合 

分 类 号：R552.2[医药卫生—血液循环系统疾病]