烟酰水杨酸对正常家兔和大鼠血脂的影响及毒理实验  

The Lipid-regulating Effects of Nicotinylsalicylic Acid on Rabbits and Its Toxicological Assay

作　　者：丁一上[1] 杨光[1] 刘梅[1] 安进莉[1] 郑志红[1] 吴越[1] 

机构地区：[1]石河子大学药物研究中心,新疆石河子832002

出　　处：《石河子大学学报（自然科学版）》2005年第3期296-298,共3页Journal of Shihezi University(Natural Science)

基　　金：国家重点科技项目(攻关)计划(96-901-01-70)

摘　　要：为了解烟酰水杨酸的调血脂和毒性作用,分别观察了烟酰水杨酸对正常家兔和大鼠血脂代谢的影响及小鼠毒理试验。结果表明:烟酰水杨酸能降低正常家兔、大鼠血中TC、TG和LDL-C,升高HDL-C;烟酰水杨酸LD50为5516.96±647.35mg/kg,Ames试验为阴性。In order to understand the lipid-regulating effects of nicotinylsalicylic acid on serum lipids and its toxity, we observed the lipid-regulating effects of nicotinylsalicylic acid on normal rabbits and rats. The results showed that nicotinylsalicylic acid could significantly reduce serum cholesterol（TC）, triglyc-eride（TG）,and low-density lipoprotein-cholesterol（LDL-C） concentrations,and increase the high-density lipoprotein-cholesterol （HDL-C）concentrations. LD50 of nicotinylsalicylic acid was 5516.96 ± 647.35 mg/kg, and Ames test was negative.

关 键 词：烟酰水杨酸 血脂 LD50 AMES试验 

分 类 号：R972.6[医药卫生—药品]