IGF-1对窒息新生儿心肌损伤的保护作用  

The effects of IGF-1 on myocardial damage in neonates with asphyxia.

作　　者：李利[1] 董旭东[1] 吴莉[1] 焦存仙[1] 李献珍[1] 曾明辉[1] 

机构地区：[1]云南省第一人民医院,650032

出　　处：《中国优生与遗传杂志》2005年第9期72-73,共2页Chinese Journal of Birth Health & Heredity

基　　金：云南省卫生厅应用基础研究资助

摘　　要：目的探讨胰岛素样生长因子-1(IGF-1)对窒息后心肌损伤的保护作用。方法选择18例窒息后伴心肌损伤的新生儿,其中轻度窒息11例,重度窒息7例,均为足月适于胎龄儿,分别在急性期和恢复期取外周静脉血,用于IGF-1和CK-MB测定。12例正常足月儿作为对照。IGF-1用ELISA法测定,CK-MB用电-化学发光法测定。结果窒息患儿急性期CK-MB显著高于对照组及恢复期,IGF-1显著低于对照组及恢复期(P均<0.01),重度窒息组CK-MB高于轻度窒息组(P<0.01),而IGF-1低于轻度窒息组(P<0.05)。IGF-1与CK-MB呈中度负相关(r=-0.600,P=0.000)。结论IGF-1参与了窒息损伤病理过程,且对窒息后心肌损伤有保护作用。IGF-1及CK-MB可作为预测窒息严重程度的指标。Objective： To explore the effects of insulin - like growth factor - 1 （ IGF - 1 ） on myocardial damage in neonates with asphyxia . Methods：IS post- asphyxia neonates with myocardial damage,7 with severe asphyxia and 11 with mild asphyxia,were recruited. Bloods were taken at acute and recovery phase respectively for detection of IGF - 1 by ELISA and CK - MB by electrochemiluminescence. 12 normal neonates were colhcted as control. Results：①serum IGF- 1 levels were markedly higher and CK- MB markedly lower in acute phases than in recovery phases in neonates with asphyxia and in control group.②IGF- 1 were increased and CK- MB decreased in severe asphyxia group compared with mild asphyxia group（ P 〈 0.05）. The levels of IGF- 1 were negatively correlated with CK- MB levels. Conclusions： ①IGF- 1 may implicate in the pathogenesis of asphyxia and have an effect in protection of myocardial damage in neonates with asphyxia.②IGF- 1 and CK - MB would be as markers of predicting asphyxia severity.

关 键 词：IGF-1 CK-MB 窒息 婴儿 新生 心肌损伤 

分 类 号：R722.1[医药卫生—儿科]