肠上皮细胞紧密连接的生物学功能及在肠屏障中的作用  

The biological functions of intestinal epithelial tight junctions and its role in intestinal barrier

作　　者：高志光[1] 秦环龙[1] 

机构地区：[1]上海交通大学附属第六人民医院普外科,上海200233

出　　处：《肠外与肠内营养》2005年第5期299-302,共4页Parenteral & Enteral Nutrition

摘　　要：紧密连接是肠上皮细胞间的主要连接方式,对维持上皮细胞极性及调节肠屏障的通透性发挥着重要的作用。因此,维持肠上皮的完整性对于保护肠道屏障功能、防止细菌内毒素及毒性大分子物质进入体内具有重要意义。作者就紧密连接在肠上皮中的生物学功能、分子调控机制及影响因素作一综述,旨在为改善肠屏障功能提供有益的帮助。Tight junctions（TJs） are the primary junctions between intestinal epithelia. TJs serve as the maintenance of epithelial cell polarity and the rate-limiting barrier to passive movement of hydrophilic solutes across intestinal epithelia. It plays an important role in maintaining integral intestinal epithelia, protecting intestinal barrier and preventing bacterial endotoxin and other toxin into body. This review is about biological functions, molecular regulating mechanisms of intestinal epithelial tight junctions and some factors affecting on them.

关 键 词：紧密连接 细胞极性 闭锁蛋白 Claudin蛋白 

分 类 号：R333[医药卫生—人体生理学]