微晶纤维素的定向硫酸酯化修饰及其结构表征  

REGIOSELECTIVE SULFATION FOR MODIFICATION OF MICROCRYSTALLINE CELLULOSE AND ITS STRUCTURAL CHARACTERIZATION

作　　者：王兆梅[1] 李琳[1] 胡松青[1] 肖蕾[1] 

机构地区：[1]华南理工大学轻工与食品学院,广东广州510640

出　　处：《林产化学与工业》2005年第3期107-110,共4页Chemistry and Industry of Forest Products

基　　金：广东省自然科学基金资助项目(000453);华南理工大学自然科学基金资助项目(040045)

摘　　要：为了构建具有不同取代模式的纤维素硫酸酯化学库,用以研究其构效关系,提出用定向硫酸酯化修饰微晶纤维素(MCC)的方法控制硫酸酯基在纤维素硫酸酯上的位置与分布。通过对MCC选择性酰氯酯化,向C-6引入大体积保护基团(CH3)3COC—,C-6被保护的中间产物经过硫酸酯化和脱保护基团反应,得到两种纤维素硫酸酯Na-MCS1和Na-MCS2,通过红外光谱、紫外-可见光谱和13CNMR鉴定了中间产物和目标产物的结构,定量13CNMR揭示了Na-MCS1和Na-MCS2的硫酸酯基取代模式分别为C-6、C-2位同时取代和C-2位取代。In order to establish a chemical stock of cellulose sulfate analogues having different substitution patterns for investigating structure-efficacy relationship, a method for regioseleetive sulfation of mierocrystalline cellulose （MCC） was described to control the position and distribution of sulfate groups in cellulose sulfates. The bulky protective group （CH3）3COC- was introduced at C_6-hydroxyl group by selective pivaloylation of MCC. Sulfation of the C_6 -substituted intermediate followed by depivaloylation give two cellulose sulfates, coded as Na-MCS1 and Na-MCS2. The structures of the intermediates and the aimed products were confirmed by IR, UV and ^13C NMR spectra. The sub- stitution patterns disclosed by quantitative ^13C NMR showed that Na-MCS1 had sulfate groups both at C_6 and C_2, and Na-MCS2 only at C_2.

关 键 词：微晶纤维素 定向硫酸酯化 结构表征 

分 类 号：TQ352.79[化学工程]