双氯灭痛直肠给药治疗下尿路术后并发的膀胱无抑制性收缩  

Rectal diclofenac for the management of postoperative uninhibited contraction of bladder

作　　者：徐耀庭[1] 陈修诚[1] 常威[1] 傅梧[1] 白进良[1] 

机构地区：[1]兰州医学院第一附属医院泌尿外科

出　　处：《中华泌尿外科杂志》1996年第5期295-297,共3页Chinese Journal of Urology

摘　　要：对３０例下尿路术后并发的膀胱无抑制性收缩患者按随机化顺序，采用单盲交替给药法，分别用自制双氯灭痛胶浆剂１００ｍｇ直肠给药和异搏定１０ｍｇ静注进行治疗。症状改善后复发或未改善者２小时后交叉用药。结果显示：双氯灭痛治疗总有效率为８８．５％，异搏定总有效率７５％，两者比较差异无显著性（ｐ＞０．０５），但双氯灭痛显效率和作用持续时间明显优于异搏定（Ｐ＜０．０５，Ｐ＜０，００１），且无明显副作用。因此认为双氯灭痛是一种治疗膀胱无抑制性收缩的较理想用药。Rectal diclofenac mucilloid(100mg)or intravenous isoptin(10mg)was given to 30 patients after lower urinary tract surgery for the relief of uninhibited bladder contraction on a single blind crossover trial basis.Alternative use of the two agents was given again 2 hours later if necessary.The total effective rate of rectal diclofenac was 88.5% and that of intravenous isoptin 75.0%(P>0.05).The mean effect-lasting time of rectal diclofenac was 25.5 ±12.3h being significantly higher than that of intravenous isoptin(P<0.001).No significant adverse side reaction was observed.Rectal diclofenac was claimed to be the better agent for the relief of postoperative uninhibited bladder contraction.

关 键 词：双氯酚酸 膀胱疾病 直肠给药 无抑制性收缩 

分 类 号：R694.505[医药卫生—泌尿科学] R983[医药卫生—外科学]