阿托伐他汀对老年高血压患者大动脉弹性的影响  

Effect of atorvastatin on aortic elasticity in elderly patients with hypertension

作　　者：王建富[1] 秦连芝[1] 李晶[1] 武善芬[1] 谭小霞[1] 伦知见[1] 

机构地区：[1]山东省临沂市沂水中心医院心内科,276400

出　　处：《中国综合临床》2005年第11期975-976,共2页Clinical Medicine of China

摘　　要：目的观察阿托伐他汀对老年单纯收缩期高血压并高胆固醇血症患者脉压及大动脉弹性的影响。方法62例老年单纯收缩期高血压(Ⅰ级)并高胆固醇血症患者服用阿托伐他汀6个月,分别于服用前后检测血脂并行超声心动图检查,升主动脉弹性用β指数表示。结果服用阿托伐他汀6个月后,收缩压从(154±13)mmHg下降到(146±12)mmHg,舒张压从(85±9)mmHg下降到(81±8)mmHg,脉压从(69±10)mmHg下降到(65±7)mmHg(P<0.05),β指数从(27.4±9.7)下降到(14.3±5.9)(P<0.01)。结论阿托伐他汀可改善老年单纯收缩期高血压并高胆固醇血症患者的大动脉弹性并使血压及脉压下降。Objective To study the effect of atorvastatin on pulse pressure and aortic elasticity in elderly patients with isolated systolic hypertension and hypercholesterolemia. Methods 62 elderly patients with isolated systolic hypertension and hypercholesterolemia were administered atorvastatin for 6 months. The blood lipid was detected and the echocardiology was performed before and after medication. Elevating aortic elasticity was expressed by β index. Results After 6-month medication,systolic blood pressure decreased from （ 154 ± 13 ） mmHg to （ 146 ± 12） mmHg,diastolic blood pressure from （85 ±9） mmHg to （81 ±8）mmHg,pulse pressure from （69 ±10） mmHg to （65±7） mmHg （P〈0.05） and β index from （27.4±9.7） to （14.3±5.9） （P〈0.01）.Conclusion Atorvastatin can improve aortic elasticity and lower the pulse pressure in elderly patients with isolated systolic hypertension and h＇ypereholesterole mia.

关 键 词：高血压 阿托伐他汀 老年人 高胆固醇血症 

分 类 号：R544.1[医药卫生—心血管疾病]