肌钙蛋白I测定在急重症患者监测中的作用  

The role of troponin I in surveillance of critically ill patients

作　　者：李毅[1] 于学忠[1] 王仲[1] 马遂[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院急诊科,北京100730

出　　处：《中国综合临床》2005年第11期978-980,共3页Clinical Medicine of China

摘　　要：目的探讨急重症患者的肌钙蛋白I(cTnI)变化,并分析其与预后的关系。方法136例急重症患者,于入院后6h及24h测定cTnI浓度。记录患者的性别、年龄、心电图变化及预后等,评估其cTnI升高率。分析cTnI与肌酸激酶及其同工酶的相关性。结果47例患者cTnI升高,升高率为35%。cTnI与肌酸激酶及其同工酶呈明显正相关。cTnI升高的前6位疾病为心功能不全、心律失常、肺部感染、休克、电解质紊乱和肺栓塞。cTnI升高组病死率较正常组高。结论急重症患者cTnI升高,与肌酸激酶及其同工酶相关。cTnI升高患者预后差。cTnI测定可作为急重症患者预后监测的一项可靠指标。Objective To investigate the troponin I （cTnI） changes in critically ill patients and analyze its prognostic function. Methods cTnI levels were measured in 136 critically ill patients at 6h and 24h on admission. The elevated rate was calculated. Age,sex,cardiac changes and prognosis were recorded. The correlation between cTnI and creatine kinase （CK） as well as MB-isoenzyme of creatine kinase （CK-MB） was analyzed. Results cTnI in 47 cases was increased, with the increasing rate of 35%. cTnI was positively correlated with CK and CK-MB. The first six diseases with increased cTnI were cardiac dysfunction, arrhythmias, pulmonary infection, shock, electrolyte disturbance and pulmonary embolism. The mortality rate was higher in the group with increased cTnI than that in normal group. Conclusion Increased cTnI in critically ill patients is correlated with CK and CK-MB. The patients with increased cTnI have poor prognosis, cTnI may be a reliable index for monitoring the prognosis of critically ill patients.

关 键 词：急重症 肌钙蛋白I 

分 类 号：R446.6[医药卫生—诊断学]