加减温经汤对月经病实寒证患者生殖激素及5-HT、β-EP的影响  

Effect of modified Wenjing Decoction on reproductive hormones, 5-HT and β-EP in patients with menopathy of excess-cold syndrome

作　　者：杜惠兰[1] 李清雪[1] 魏影非[2] 白凤楼[1] 李惜芳[1] 

机构地区：[1]河北医科大学中西医结合学院妇产科教研室,河北石家庄050091 [2]河北省人民医院,河北石家庄050000

出　　处：《中成药》2005年第9期1047-1050,共4页Chinese Traditional Patent Medicine

基　　金：河北省科技厅资助项目(No.99276218)。

摘　　要：目的探讨加减温经汤治疗月经病实寒证的作用机制,并从治疗角度反证月经病实寒证与5HT、βEP及生殖激素的关系。方法对60例月经病实寒证患者给与加减温经汤治疗,连续服药3个月经周期。观察临床疗效,并测定治疗前后血清5HT、βEP及生殖激素的变化。结果近期临床治愈22例(36.7),有效28例(45.7),无效10例(17.6)。治疗后血清FSH、LH、E2、βEP较治疗前明显升高(P<0.05,P<0.05,P<0.05,P<0.01),PRL、5HT明显降低(均为P<0.05),有统计学意义。结论加减温经汤在治疗月经病实寒证的同时,有改善生殖内分泌激素、调节致痛物质及镇痛物质的作用。AIM： To observe the treatment effectiveness of menopathy of excessive-cold syndrome by Modified Wenjing Decoction, and to explore the relationship among excessive-cold syndrome of menopathy and 5-HT, β-EP, and reproduetive hormones. METHODS ： Sixty patients with menopathy of excess-cold syndrome were successively treated with Modified Wenjing Decoction for three menstrual cycles. The efficacy and the changes of serum 5-HT, Bendorphine （β-EP） and reproductive hormones before and after treatment were observed. RESULTS ： 22 patients （36.7%） were short-term therapeutic effect, 28 patients（45.7% ） were effective and 10 patients（ 17.6% ） were ineffective. After treatment, the levels of serum FSH, LH, E2 , β-EP were increased significantly （ P 〈 0.05, P 〈 0.05, P 〈0.05, P 〈0.01） higher than those before treatment and the levels of serum PRL,5-HT were decreased significantly less（ both P 〈 0.05 ） than those before treatment. All of them had statistical significance. CONCLUSION： Modified Wenjing Decoction could improve the reproductive hormones and adjust the algogenic and analgesic substances undergoing treatment in patients with menopathy of excessive-cold syndrome.

关 键 词：加减温经汤 月经病 实寒证 生殖激素 5-羟色胺 Β-内啡肽 

分 类 号：R287[医药卫生—中药学]